Osteoporosis is a Health Concern Characterized by Reduced Bone Mineral Density (BMD) and Increased Risk of Fragility Fractures. Many Studies Have Investigated the Association between Genetic Variants and Osteoporosis. Polymorphism and Allelic Variations in the Vitamin D Receptor Gene (VDR) Have Been Found to Be Associated with Bone Mineral Density. However, Many Studies Have Not Been Able to Find This Association. Literature Review Was Conducted in Several Databases, Including MEDLINE/Pubmed, Scopus, EMBASE, Ebsco, Science Citation Index Expanded, Ovid, Google Scholar, Iran Medex, Magiran and Scientific Information Database (SID) for Papers Published between 2000 and 2013 Describing the Association between Fok1 and Bsm1 Polymorphisms of the VDR Gene and Osteoporosis Risk. the Majority of the Revealed Papers Were Conducted on Postmenopausal Women. Also, More Than 50% Studies Reported Significant Relation between Fok1, Bsm1 and Osteoporosis. Larger and More Rigorous Analytical Studies with Consideration of Gene-Gene and Gene-Environment Interactions Are Needed to Further Dissect the Mechanisms by Which VDR Polymorphisms Influence Osteoporosis.


Mechanical and Aerospace Engineering

Publication Status

Open Access

Keywords and Phrases

Bone density; Bsm1; Fok1; Osteoporosis; Polymorphism; Vitamin D receptor gene

International Standard Serial Number (ISSN)


Document Type

Article - Journal

Document Version

Final Version

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Publication Date

01 Jan 2014