Tissue-Engineered Heart Valves
A tissue engineered heart valve (TEHV) could serve as a living, implantable valve replacement that would grow and adapt with the patient. A TEHV consists of relevant cells seeded on or entrapped in a scaffold material which is designed to degrade as the cells produce their own extracellular matrix components. Because the valve consists of living tissue, it can grow and remodel as a patient ages, making it an especially attractive replacement option for pediatric and young adult patients. To date, using various cell sources, scaffold materials, and/or in vitro culture protocols, several laboratories have produced TEHVs with the appropriate geometry and near-native mechanical properties. TEHVs implanted in the pulmonary position in sheep in our laboratory have shown promising short-term functionality but fail to maintain good performance after several months in vivo. Upcoming TEHV research will focus on optimization of TEHV components and in vitro culture conditions in order to improve long-term function post-implant, with the hope of performing human implants in the future.
J. B. Schmidt and R. T. Tranquillo, "Tissue-Engineered Heart Valves," Heart Valves: From Design to Clinical Implantation, pp. 261-280, Springer US, Jan 2013.
The definitive version is available at https://doi.org/10.1007/978-1-4614-6144-9_11
Mechanical and Aerospace Engineering
Keywords and Phrases
Particle Image Velocimetry; Heart Valve; Scaffold Material; Ovine Model; Mechanical Conditioning
International Standard Book Number (ISBN)
Book - Chapter
© 2013 Springer US, All rights reserved.
01 Jan 2013