An optimal online feedback treatment strategy is developed for the parturient paresis of cows, based on nonlinear optimal control theory. A limitation in the development of an existing mathematical model for calcium homeostasis is addressed and the model is extended to incorporate control inputs. An optimal feedback controller is synthesized for the nonlinear system using neural networks. Though the main aim of this paper is to solve the biomedical control problem, the methodology presented in this paper is a general computational tool, which can be applied to solve a fairly general class nonlinear optimal control problems.

Meeting Name

2001 IEEE International Conference on Control Applications, 2001


Mechanical and Aerospace Engineering

Keywords and Phrases

Adaptive Critic Design; Biocontrol; Calcium Homeostasis; Feedback; Neural Nets; Neural Networks; Nonlinear Control Systems; Optimal Control; Parturient Paresis

Document Type

Article - Conference proceedings

Document Version

Final Version

File Type





© 2001 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.

Publication Date

01 Jan 2001