Silicate, Borosilicate, and Borate Bioactive Glass Scaffolds with Controllable Degradation Rate for Bone Tissue Engineering Applications I

Alternative Title

Preparation and in vitro degradation


Anderson, James M.


Bioactive glass scaffolds with a microstructure similar to that of dry human trabecular bone but with three different compositions were evaluated for potential applications in bone repair. the preparation of the scaffolds and the effect of the glass composition on the degradation and conversion of the scaffolds to a hydroxyapatite (HA)-type material in a simulated body fluid (SBF) are reported here (Part I). the in vitro response of osteogenic cells to the scaffolds and the in vivo evaluation of the scaffolds in a rat subcutaneous implantation model are described in Part II. Scaffolds (porosity = 78-82%; pore size = 100-500 microm) were prepared using a polymer foam replication technique. the glasses consisted of a silicate (13-93) composition, a borosilicate composition (designated 13-93B1), and a borate composition (13-93B3), in which one-third or all of the SiO2 content of 13-93 was replaced by B2O3, respectively. the conversion rate of the scaffolds to HA in the SBF increased markedly with the B2O3 content of the glass. Concurrently, the pH of the SBF also increased with the B2O3 content of the scaffolds. the compressive strengths of the as-prepared scaffolds (5-11 MPa) were in the upper range of values reported for trabecular bone, but they decreased markedly with immersion time in the SBF and with increasing B2O3 content of the glass. the results show that scaffolds with a wide range of bioactivity and degradation rate can be achieved by replacing varying amounts of SiO(2) in silicate bioactive glass with B2O3.


Materials Science and Engineering

Keywords and Phrases

Animals; Bone and Bones/Physiology; Borates/Chemistry; Boron Compounds/Chemistry; Compressive Strength; Durapatite/Chemistry; Glass/Chemistry; Humans; Kinetics; Materials Testing; Microscopy-Electron-Scanning; Models-Biological; Molecular Weight; Rats; Silicates/Chemistry; Surface Properties; Tissue Engineering/Methods; Tissue Scaffolds/Chemistry

International Standard Serial Number (ISSN)

1549-3296; 1552-4965

Document Type

Article - Journal

Document Version


File Type





© 2010 Wiley-Blackwell, All rights reserved.

Publication Date

01 Jan 2010