Keywords and Phrases
Restricted Diffusion; Porous Adsorbents; Relative Permeability; Biospecific Adsorption
"A restricted pore diffusion model is presented and employed as the principle theoretical tool to investigate salient characteristics of the permeability behavior of biologically active macromolecules in porous affinity chromatography media, when these large adsorbate molecules are adsorbed onto available vacant ligands immobilized therein. The contributions of steric hindrance at the entrance to the pores and frictional resistance within the pores to the overall restriction to pore diffusion, accompanied by the effects of pore size distribution, pore connectivity of the adsorbent, molecular dimension of adsorbate and ligand, and the fractional saturation of adsorption sites (ligands), are considered. Porous affinity matrices having dilute and high ligand concentrations are examined, and the permeability of the adsorbate in porous networks of connectivity nT is studied by means of effective medium approximation (EMA) numerical solutions. The detailed trends of the permeability of the adsorbate encountered in affinity adsorption systems of Porous Silica and Superose™ 6 with dilute and high ligand concentrations, are described and presented in numerous Tables. Results of this work may be of importance in studies involving the modeling, prediction of the dynamic behavior, design, and control of affinity chromatography (biospecific adsorption) adsorbents"--Abstract, page iii.
Liapis, Athanasios I.
Findley, Marshall E., 1927-1991
Siehr, Donald J.
Rigler, A. K.
Chemical and Biochemical Engineering
M.S. in Chemical Engineering
North Atlantic Treaty Organization. Scientific Affairs Division
Weldon Spring Fund
University of Missouri--Rolla
xii, 109 pages
© 1989 Nikolaos Panagiotis Kolliopoulos, All rights reserved.
Thesis - Restricted Access
Diffusion -- Mathematical models
Molecules -- Analysis
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Link to Catalog Record
Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.http://merlin.lib.umsystem.edu/record=b2208674~S5
Kolliopoulos, Nikolaos Panagiotis, "Restricted diffusion of molecules in porous affinity chromatography adsorbents" (1989). Masters Theses. 787.
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