Keywords and Phrases
Breast Cancer; Nanoparticles
"Nanotechnology incorporated with molecular biology became a promising way to treat cancer. The size of nanoparticles enables them to overcome the side effects noticed in cancer treatment like chemotherapy and surgery. Various types and shapes of nanoparticles have been synthesized and used in drug delivery to tumor sites. However, one of problems of using these nanoparticles is the aggregation after injecting them into human body due to flow rate of bloodstream. The coagulation and aggregation will result in clogging blood vessel and lower therapeutic efficacy.
In this thesis, a solution to the aggregation problem was proposed, which is coating biopolymer on nanoparticles (NPs). The experimental sections covered synthesis and characterization of breast cancer specific targeting drug-encapsulated NPs and biopolymer coating on the surface of Au-Fe3O4 NPs for thermal therapy. Furthermore, in vitro studies of these NPs with breast cancer cells were also included. The specific targeting anticancer drug-encapsulated NRs showed significant inhibition in BT-474 breast cancer cell growth. The Au-Fe3O4 NPs has a possibility to treat cancer cells using the thermal therapy approach"--Abstract, page iv.
Chemical and Biochemical Engineering
M.S. in Chemical Engineering
Missouri University of Science and Technology
Journal article titles appearing in thesis/dissertation
- Bioresponsive polymer coating on targeted drug nanorods
- Polymer coating on Au-Fe3O4 nanoparticles
xii, 56 pages
© 2016 Tunyaboon Laemthong
Thesis - Open Access
Breast -- Cancer
Electronic OCLC #
Laemthong, Tunyaboon, "Bioresponsive polymer coating on nanoparticles" (2016). Masters Theses. 7604.