"In this work, an experimental design was employed to investigate the effects of different operating conditions on the isomerization of lactose to lactulose by using strong basic anion exchange resin (AMBERLITE-IRA 402). Temperature, resin/lactose mass ratio and pH were considered to be the three factors affecting the conversion of lactose. Box-Behnken design was then used to optimize the operating conditions for maximum response and also to study the various interaction and main effects of the factors. The analysis of variance (ANOVA) of the experimental data showed a high correlation coefficient R² (0.99) and a low root mean square error (2.84) values for the second order regression model for the experimental design, indicating the good predictive nature of the model. The results gave an operating condition of temperature = 80.8⁰C, resin/lactose mass ratio = 0.371 and pH = 10.3 for maximum response.
A kinetic model was deduced on the basis of Langmuir-Hinshelwood-Hougen-Watson formulation and the experimental data was later fit to the model by using least square approximation to estimate the activation energy (Ea), pre-exponential factor (A0) and the adsorption coefficient (K₁). The effect of resin bead diameter was also studied and the results indicated that the bead diameter of the as-received resin is sufficiently small to eliminate internal diffusion resistances."--Abstract, page iii.
Sitton, Oliver C., 1951-
Samaranayake, V. A.
Book, Neil L.
Chemical and Biochemical Engineering
M.S. in Chemical Engineering
Missouri University of Science and Technology
xvi, 116 pages
© 2010 Arvind Nanduri, All rights reserved.
Thesis - Open Access
Chemical kinetics -- Mathematical models
Ion exchange resins
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Electronic OCLC #
Link to Catalog Record
Nanduri, Arvind, "Optimization of parameters and study of kinetics in lactulose production by lactose isomerization using strong basic anion exchange resin" (2010). Masters Theses. 6857.