Masters Theses


A high-performance amperometric biosensor system utilizing electrolytic gas bubbles

Alternative Title

High performance amperometric biosensor system utilizing electrolytic gas bubbles


Jongwon Park


"Most of the biochemical sensors exhibit instabilities such as baseline drift and sensitivity degradation. On on-demand in situ self-diagnosis and self-calibration functionality of biochemical sensors is indispensable for continuous and reliable monitoring. An on-chip electrochemical actuation method (water electrolysis) was employed to achieve this novel functionality. New integrated microfluidic systems are proposed for intelligent glucose and lactate monitoring. The oxygen microenvironment created by the electrolytic bubbles provides novel functionalities to glucose and lactate sensors: the one-point in situ self-calibration (zero-point), extension of dynamic range, and increase in sensitivity. The properties of electrolytically generated gas bubble were first investigated with a commercial fiber optic oxygen sensor. A microsystem including a fluidic structure and electrolysis electrodes is prepared by microfabrication technologies. A thick photoresist was used to prepare a template for the molding process of a polydimethylsiloxane (PDMS) cover layer to define the fluidic structure. The electrode substrate was a silicon wafer with a silicon nitride layer coating. The controlled oxygen microenvironment effectively manipulated the sensor responses. This electrochemically-driven fluidic biosensor system appears to be a promising platform of minimally invasive biosensing devices or extracorporeal devices for continuous monitoring due to its simple and miniaturized structure"--Abstract, leaf iii.


Electrical and Computer Engineering

Degree Name

M.S. in Electrical Engineering


University of Missouri--Rolla

Publication Date

Fall 2005


viii, 40 leaves


© 2005 Jongwon Park, All rights reserved.

Document Type

Thesis - Citation

File Type




Library of Congress Subject Headings

Conductometric analysis

Thesis Number

T 8905

Print OCLC #


Link to Catalog Record

Full-text not available: Request this publication directly from Missouri S&T Library or contact your local library.

This document is currently not available here.

Share My Thesis If you are the author of this work and would like to grant permission to make it openly accessible to all, please click the button above.