Modelling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials : Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies
Keywords and Phrases
Freeze drying in vials; Lyophilization in vials; Surface geometry of moving interface; Velocity of moving interface; Distribution of bound water
"A rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. The results in this work strongly motivate the aggressive control of freeze drying, and it is found that heat input control that runs the process close to the melting and scorch temperature constraints yields (i) faster drying times, and (ii) more uniform distributions of temperature and concentration of bound water at the end of the secondary drying stage"--Abstract, page iv.
Liapis, Athanasios I.
Reed, X. B., Jr.
Avula, Xavier J. R.
Chemical and Biochemical Engineering
M.S. in Chemical Engineering
University of Missouri--Rolla
xii, 239 pages
© 1998 Patrick Paul Sheehan, All rights reserved.
Thesis - Restricted Access
Freeze-drying -- Research
Freeze-drying -- Mathematical models
Drying -- Mathematical models
Interfaces (Physical sciences) -- Mathematical models
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Electronic OCLC #
Link to Catalog Record
Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.http://merlin.lib.umsystem.edu/record=b4063588~S5
Sheehan, Patrick P., "Modelling of the primary and secondary drying stages of the freeze drying of pharmaceutical products in vials : Numerical results obtained from the solution of a dynamic and spatially multi-dimensional lyophilization model for different operational policies" (1998). Masters Theses. 1727.
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