Masters Theses

Keywords and Phrases

Freeze drying in vials; Lyophilization in vials; Surface geometry of moving interface; Velocity of moving interface; Distribution of bound water


"A rigorous unsteady state and spatially multidimensional model is presented and solved to describe the dynamic behavior of the primary and secondary drying stages of the lyophilization of a pharmaceutical product in vials for different operational policies. The results in this work strongly motivate the aggressive control of freeze drying, and it is found that heat input control that runs the process close to the melting and scorch temperature constraints yields (i) faster drying times, and (ii) more uniform distributions of temperature and concentration of bound water at the end of the secondary drying stage"--Abstract, page iv.


Liapis, Athanasios I.

Committee Member(s)

Reed, X. B., Jr.
Avula, Xavier J. R.


Chemical and Biochemical Engineering

Degree Name

M.S. in Chemical Engineering


University of Missouri--Rolla

Publication Date

Spring 1998


xii, 239 pages

Note about bibliography

Includes bibliographical references.


© 1998 Patrick Paul Sheehan, All rights reserved.

Document Type

Thesis - Restricted Access

File Type




Subject Headings

Freeze-drying -- Research
Freeze-drying -- Mathematical models
Drying -- Mathematical models
Interfaces (Physical sciences) -- Mathematical models

Thesis Number

T 7485

Print OCLC #


Electronic OCLC #


Link to Catalog Record

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