"We have investigated Freeze Extrusion Fabrication (FEF) of 13-93 bioactive glass to fabricate three dimensional scaffolds for bone tissue engineering. Bioactive glass paste was prepared for consistent extrusion through micro-nozzle and controlled porosity scaffolds were fabricated using additive manufacturing FEF. CAD models were prepared for different scaffold designs and computer controlled layer-by-layer deposition of pseudoplastic paste was carried out to in accordance. Liquid nitrogen assisted freezing of pastes was used for the consolidation of deposited layers. Post processing binder burnout and sintering schedules were designed for evaporation of organic binder and densification of glass. Sintering shrinkage was measured, and X-ray diffraction analysis was carried out to evaluate the nature of the sintered glass. SEM images of the sintered scaffolds were observed for pore interconnectivity required for tissue ingrowth. The sintered scaffolds demonstrated average compressive strength of 136 MPa. This is equivalent to human cortical bone compressive strength and it is the highest reported value with the additive manufacturing of bioactive glass"--Abstract, page iv.
Leu, M. C. (Ming-Chuan)
Landers, Robert G.
Rahaman, M. N., 1950-
Mechanical and Aerospace Engineering
M.S. in Manufacturing Engineering
Missouri University of Science and Technology. Center for Bone Tissue Repair and Regeneration
Missouri University of Science and Technology
ix, 50 pages
© 2010 Nikhil Digamber Doiphode, All rights reserved.
Thesis - Restricted Access
Biomedical materials -- Testing
Glass in medicine
Solid freeform fabrication
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Electronic access to the full-text of this document is restricted to Missouri S&T users. Otherwise, request this publication directly from Missouri S&T Library or contact your local library.http://merlin.lib.umsystem.edu/record=b8244259~S5
Doiphode, Nikhil D., "Freeze extrusion fabrication of 13-93 bioactive glass scaffolds for bone repair" (2010). Masters Theses. 129.
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