Masters Theses


"We have investigated Freeze Extrusion Fabrication (FEF) of 13-93 bioactive glass to fabricate three dimensional scaffolds for bone tissue engineering. Bioactive glass paste was prepared for consistent extrusion through micro-nozzle and controlled porosity scaffolds were fabricated using additive manufacturing FEF. CAD models were prepared for different scaffold designs and computer controlled layer-by-layer deposition of pseudoplastic paste was carried out to in accordance. Liquid nitrogen assisted freezing of pastes was used for the consolidation of deposited layers. Post processing binder burnout and sintering schedules were designed for evaporation of organic binder and densification of glass. Sintering shrinkage was measured, and X-ray diffraction analysis was carried out to evaluate the nature of the sintered glass. SEM images of the sintered scaffolds were observed for pore interconnectivity required for tissue ingrowth. The sintered scaffolds demonstrated average compressive strength of 136 MPa. This is equivalent to human cortical bone compressive strength and it is the highest reported value with the additive manufacturing of bioactive glass"--Abstract, page iv.


Leu, M. C. (Ming-Chuan)

Committee Member(s)

Landers, Robert G.
Rahaman, M. N., 1950-


Mechanical and Aerospace Engineering

Degree Name

M.S. in Manufacturing Engineering


Missouri University of Science and Technology. Center for Bone Tissue Repair and Regeneration


Missouri University of Science and Technology

Publication Date

Fall 2010


ix, 50 pages

Note about bibliography

Includes bibliographical references.


© 2010 Nikhil Digamber Doiphode, All rights reserved.

Document Type

Thesis - Restricted Access

File Type




Subject Headings

Biomedical materials -- Testing
Extrusion process
Glass in medicine
Solid freeform fabrication
Tissue scaffolds

Thesis Number

T 9724

Print OCLC #


Electronic OCLC #


Link to Catalog Record

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