Glucose Oxidase (GOD)-coupled Amperometric Microsensor with Integrated Electrochemical Actuation System

Jongwon Park
Chang-Soo Kim, Missouri University of Science and Technology
Minsu Choi, Missouri University of Science and Technology
Shanrui Zhang

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Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue, a novel solid-state glucose oxidase-coupled amperometric biosensor with integrated electrochemical actuation system has been designed and validated. There are two key components of the proposed glucose biosensor: solid-state GOD-coupled thin-lm amperometric sensing element andO 2 depleting/saturating built-in electrochemical actuator. The actuator can be used to accomplish in-situ 1-point self-calibration by depleting O 2 (i.e., by simulating glucose-free environment). Also, it can be used at the same time to extend the proposed sensor''s linear detection range by in ating O 2 (i.e., by enhancing glucose sensitivity). A prototype sensor was fabricated and a series of lab experiments was conducted. Collected data assures that the proposed sensor effectively establishes the zero calibration point and signi cantly enhances its measurement sensitivity and con dence.