Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. To address this deficiency, a novel needle-type biosensor system with fully automated operations is being developed, in which a novel oxidase-coupled amperometric sensor with oxygen depleting/generating actuator is interfaced with an electrochemical instrument and a perfusion system. Labview virtual instrument has been also developed to oversee the automatic control of the prototype sensor. Using the proposed system, a large amount of data can be rapidly collected for more effective sensor characterization and more advanced sensor designs. Autonomous and continuous sensing and self-calibration with minimal human intervention is also envisioned.

Meeting Name

IEEE Instrumentation and Measurement Technology Conference: IMTC (2006: Apr. 24-27, Sorrento, Italy)


Electrical and Computer Engineering

Second Department

Biological Sciences


National Science Foundation (U.S.)


This work is partly supported by NSF ECS-0400913 and NSF ECS-0427360.

Keywords and Phrases

Actuator; Automation; Calibration; Continuous Calibration/Sensing; GOD (Glucose Oxidase); LOD (Lactate Oxidase); LabView; Needle Based Amperometric Sensor; Solid-State Biosensor; Water Electrolysis; Continous Calibration; Integrated Electrochemical Actuation; Amperometric Sensors; Biosensors; Diagnosis; Microsensors

International Standard Book Number (ISBN)


International Standard Serial Number (ISSN)


Document Type

Article - Conference proceedings

Document Version

Final Version

File Type





© 2006 Institute of Electrical and Electronics Engineers (IEEE), All rights reserved.

Publication Date

01 Apr 2006