Doctoral Dissertations

Keywords and Phrases

NMR; Spectroscopy; Spin-Lattice Relaxation

Abstract

This research develops and refines the Split Inversion Pulse and Recovery (SIP R) methodology for spin-lattice relaxation (T₁) measurements in NMR spectroscopy. SIP R introduces a two-scan difference technique using a split inversion pulse sequence, where the 180° pulse is split into two 90° pulses phase-shifted with respect to each other. This approach simplifies data fitting, requiring only two parameters to extract T₁ values, compared to the traditional inversion-recovery method, which needs three. The SIP-R-DS and SIP-R-S adaptations extend this framework by incorporating selective NMR resonance excitations, enhancing its applicability to cross-polarization experiments and enabling unobstructed NOE measurements. These adaptations also improve measurements in complex molecular systems with overlapping signals, allowing for tailored excitation and optimized data acquisition. To further improve efficiency, the RAPTOR (Rapid Acquisition Pulse Train to Observe Relaxation) technique was developed, utilizing the SIP-R concept to significantly reduce experimental duration without compromising accuracy. By integrating the Flip-Flop method, RAPTOR achieves T₁ measurements in under five minutes. Together, these innovations advance NMR relaxometry, offering a versatile, efficient framework for T₁ measurements across a broad range of molecular systems and environments.

Advisor(s)

Woelk, Klaus

Committee Member(s)

Choudhury, Amitava
Grubbs, Garry S.
Winiarz, Jeffrey G.
Abdelrahman, Magdy

Department(s)

Chemistry

Degree Name

Ph. D. in Chemistry

Publisher

Missouri University of Science and Technology

Publication Date

Summer 2025

Journal article titles appearing in thesis/dissertation

Paper I, found on pages 4-25, has been published in The Journal of Magnetic Resonance, in June of 2023,
Paper II, found on pages 26-48, has been accepted by The Journal of Magnetic Resonance, in April 2025.
Paper III, found on pages 49-58, is intended for submission to The Journal of Magnetic Resonance.

Pagination

xiii, 72 pages

Note about bibliography

Includes_bibliographical_references_(pages 65-71)

Rights

© 2025 Zachary Mayes , All Rights Reserved

Document Type

Dissertation - Open Access

File Type

text

Language

English

Thesis Number

T 12515

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