Doctoral Dissertations
Abstract
"Ethanol and ionizing radiation exposure are independently known to cause tissue damage through various mechanisms. Non-enzymatic and enzymatic metabolism of ethanol, the latter via the cytochrome P₄₅₀2E1-dependent pathway, produces free radicals which deplete cellular glutathione (GSH). Ionizing radiation exposure has been shown to induce lipid peroxidation, DNA damage, protein oxidation, and GSH depletion, as well. It was postulated that initial exposure to ethanol, followed by ionizing radiation, would result in heightened oxidative stress. The in vitro model used in this investigation was HepG2 cells (human hepatocellular liver carcinoma cell line), while the in vivo model was Cd-1 mice"--Abstract, page iii.
Advisor(s)
Ercal, Nuran
Committee Member(s)
Ma, Yinfa
Reddy, Prakash
Huang, Yue-wern
Sinn, Ekkehard
Department(s)
Chemistry
Degree Name
Ph. D. in Chemistry
Sponsor(s)
Matthews Foundation
Missouri. Department of Higher Education
Publisher
University of Missouri--Rolla
Publication Date
Fall 2007
Pagination
xiii, 132 pages
Note about bibliography
Includes bibliographical references (pages 117-131).
Rights
© 2007 Joshua Ogony, All rights reserved.
Document Type
Dissertation - Open Access
File Type
text
Language
English
Subject Headings
Alcohol
Antioxidants
Ionizing radiation
Oxidative stress
Thesis Number
T 9221
Print OCLC #
243609202
Electronic OCLC #
191821449
Link to Catalog Record
Recommended Citation
Ogony, Joshua, "Effects of combined exposure to ethanol and ionizing radiation on the antioxidant status of in vitro and in vivo models" (2007). Doctoral Dissertations. 1924.
https://scholarsmine.mst.edu/doctoral_dissertations/1924
