"Ethanol and ionizing radiation exposure are independently known to cause tissue damage through various mechanisms. Non-enzymatic and enzymatic metabolism of ethanol, the latter via the cytochrome P₄₅₀2E1-dependent pathway, produces free radicals which deplete cellular glutathione (GSH). Ionizing radiation exposure has been shown to induce lipid peroxidation, DNA damage, protein oxidation, and GSH depletion, as well. It was postulated that initial exposure to ethanol, followed by ionizing radiation, would result in heightened oxidative stress. The in vitro model used in this investigation was HepG2 cells (human hepatocellular liver carcinoma cell line), while the in vivo model was Cd-1 mice"--Abstract, page iii.
Ph. D. in Chemistry
Missouri. Department of Higher Education
University of Missouri--Rolla
xiii, 132 pages
© 2007 Joshua Ogony, All rights reserved.
Dissertation - Open Access
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Ogony, Joshua, "Effects of combined exposure to ethanol and ionizing radiation on the antioxidant status of in vitro and in vivo models" (2007). Doctoral Dissertations. 1924.