Abstract
The use of nanoparticles in agrichemical formula and food products as additives has increased their chances of accumulation in humans via oral intake. Due to their potential toxicity, it is critical to understand their fate and distribution following oral intake. Cerium oxide nanoparticle (CeO2NP) is commonly used in agriculture and is highly stable in the environment. as such, it has been used as a model chemical to investigate nanoparticle's distribution and clearance. based on their estimated human exposure levels, 0.15–0.75 mg/kg body weight/day of CeO2NPs with different sizes and surface charges (30–50 nm with negative charge and <25 >nm with positive charge) were gavage into C57BL/6 female mice daily. after 10-d, 50% of mice in each treatment were terminated, with the remaining being garaged with 0.2 mL of deionized water daily for 7-d. Mouse organ tissues, blood, feces, and urine were collected at termination. at the tested levels, CeO2NPs displayed minimal overt toxicity to the mice, with their accumulation in various organs being negligible. Fecal discharge as the predominant clearance pathway took less than 7-d regardless of charges. Single particle inductively coupled plasma mass spectrometry analysis demonstrated minimal aggregation of CeO2NPs in the gastrointestinal tract. These findings suggest that nanoparticle additives >25 nm are unlikely to accumulate in mouse organ after oral intake, indicating limited impacts on human health.
Recommended Citation
X. Ma et al., "Fate and Distribution of Orally-Ingested CeO2-Nanoparticles based on a Mouse Model: Implication for Human Health," Soil and Environmental Health, vol. 1, no. 2, article no. 100017, Elsevier, Jun 2023.
The definitive version is available at https://doi.org/10.1016/j.seh.2023.100017
Department(s)
Chemistry
Second Department
Chemical and Biochemical Engineering
Publication Status
Open Access
Keywords and Phrases
Cerium oxide nanoparticles; Different charge; Different size; Environmental impacts; Oral intake; SP-ICP-MS
International Standard Serial Number (ISSN)
2949-9194
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Elsevier, All rights reserved.
Publication Date
01 Jun 2023
Included in
Biochemistry, Biophysics, and Structural Biology Commons, Biomedical Engineering and Bioengineering Commons, Chemical Engineering Commons, Chemistry Commons
Comments
National Institutes of Health, Grant P30-ES029067