Capillary Gas Chromatographic Separation Of Enantiomers With Stable Dipentyl-α, Β- And Γ-cyclodextrin-derivatized Stationary Phases
Liquid and amorphous solid pentyl derivatives of α-, β- and γ-cyclodextrin were evaluated as gas chromatographic (GC) chiral stationary phase coatings on fused-silica capillaries. The factors controlling the physical state of the pentyl-substituted cycldodextrin derivatives were considered. Sixty-five racemic solutes were resolved, including alcohols, amines, lactones, epoxides, amino alcohols, esters, ethers, amino acids, haloalkanes, sugars and alkaloids. The pentyl-substituted α-, β- and γ-cyclodextrin stationary phases showed pronounced selectivity differences, apparently based on the size, shape and functionality of the analytes. Inclusion complexation may more readily occur at high temperatures in gas than in liquid chromatography (LC). Enantiomeric separations can be accomplished by this GC method that cannot be done by related cyclodextrin LC techniques. © 1990.
D. W. Armstrong et al., "Capillary Gas Chromatographic Separation Of Enantiomers With Stable Dipentyl-α, Β- And Γ-cyclodextrin-derivatized Stationary Phases," Analytica Chimica Acta, vol. 234, pp. 365 - 380, Elsevier, Jan 1990.
The definitive version is available at https://doi.org/10.1016/S0003-2670(00)83579-5
Keywords and Phrases
Chiral stationary phase; Cyclodextrins; Enantiomers
International Standard Serial Number (ISSN)
Article - Journal
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01 Jan 1990