N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines
Nucleophilic trifluoromethylation of aromatic N-tosylaldimines has been achieved using trifluoromethyltrimethylsilane (TMSCF3) in the presence of the in situ generated N-heterocyclic carbene catalysts. Aromatic N-tosylaldimines with electron-withdrawing as well as electron-donating groups on the aryl ring afforded the corresponding trifluoromethylated sulfonamides in moderate to good yields.
P. Reddy et al., "N-Heterocyclic Carbene-Catalyzed Trifluoromethylation of Aromatic N-Tosylaldimines," Topics in Catalysis, vol. 61, no. 7-8, pp. 699-703, Springer US, Jun 2018.
The definitive version is available at https://doi.org/10.1007/s11244-018-0912-7
Keywords and Phrases
Aldimines; Catalysis; Imidazolium; N-Heterocyclic carbene; TMSCF3; Trifluoromethylation
International Standard Serial Number (ISSN)
Article - Journal
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01 Jun 2018