Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides, polyenes and derivatives thereof. The process has been found to be especially advantageous for separation of optical isomers by electrophoresis and chromatography.
D. W. Armstrong, "Macrocyclic Antibiotics as Separation Agents," U.S. Patents, Mar 2006.
Patent Application Number
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07 Mar 2006