Nickel (II) Complexes of Naphthaquinone Thiosemicarbazone and Semicarbazone: Synthesis, Structure, Spectroscopy, and Biological Activity
Ni(II) complexes of ortho-naphthaquinone thiosemicarbazone and semicarbazone were synthesized and spectroscopically characterized. the X-ray crystal structure of both the complexes describe a distorted octahedral coordination with two tridentate mono-deprotonated ligands. in vitro anticancer studies on MCF-7 human breast cancer cells reveal that the semicarbazone derivative along with its nickel complex is more active in the inhibition of cell proliferation than the thiosemicarbazone analogue.
Z. Afrasiabi Navan et al., "Nickel (II) Complexes of Naphthaquinone Thiosemicarbazone and Semicarbazone: Synthesis, Structure, Spectroscopy, and Biological Activity," Journal of Inorganic Biochemistry, vol. 99, no. 7, pp. 1526-1531, Elsevier, Jul 2005.
The definitive version is available at http://dx.doi.org/10.1016/j.jinorgbio.2005.04.012
Keywords and Phrases
antineoplastic agent; naphthaquinone thiosemicarbazone; nickel complex; nickel(naphthaquinone semicarbazone); nickel(naphthaquinone thiosemicarbazone); semicarbazone; semicarbazone derivative; unclassified drug; antineoplastic activity; biological activity; cancer inhibition; cell proliferation; cell strain MCF 7; crystal structure; drug structure; drug synthesis; human; human cell; spectroscopy; X ray analysis; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Humans; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Naphthoquinones; Nickel; Organometallic Compounds; Semicarbazones; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Thiosemicarbazones, Mink cell focus-forming virus
International Standard Serial Number (ISSN)
Article - Journal
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