Polyamidoamine Dendrimer Microgels: Hierarchical Arrangement of Dendrimers into Micrometer Domains with Expanded Structural Features for Programmable Drug Delivery and Release
We report on the fabrication of micrometer-sized dendrimer hydrogels (µDHs) using the water-in-oil (w/o) inverse microemulsion method coupled with the highly efficient aza-Michael addition. EDA core polyamidoamine (PAMAM) dendrimer G5 (10 wt %) and poly(ethylene glycol) diacrylate (PEG-DA, Mn = 575 g/mol) (the molar ratio of amine/acrylate = 1/1) were dissolved in the water phase and added to hexane in the presence of surfactants span 80/tween 80 (5/1, w/w) (volume ratio of hexane to surfactants: 70:1) to form w/o microemulsions, in which PAMAM G5 cross-links with PEG-DA via the aza-Michael addition reaction. The resulting microgels are within 3-5 µm with relatively narrow size distribution. µDHs are pH-responsive degradable. They show good cytocompatibility and do not cause acute toxicity in vivo. Furthermore, they can realize a high loading of the hydrophobic drug CPT and enter the cells in the form of particles. The CPT and CPT/dendrimer complex can be slowly released following the zero-order release kinetics. Taken together, µDHs possessing hierarchically ordered dendrimers in micrometer domains represent a new class of microparticles with expanded structural features for programmable drug delivery and release.
J. Wang et al., "Polyamidoamine Dendrimer Microgels: Hierarchical Arrangement of Dendrimers into Micrometer Domains with Expanded Structural Features for Programmable Drug Delivery and Release," Macromolecules, vol. 51, no. 15, pp. 6111 - 6118, American Chemical Society (ACS), Aug 2018.
The definitive version is available at https://doi.org/10.1021/acs.macromol.8b01006
Chemical and Biochemical Engineering
Keywords and Phrases
Addition reactions; Dendrimers; Gels; Hexane; Inverse problems; Manganese removal (water treatment); Microemulsions; Micrometers; Polyethylene glycols; Surface active agents; Targeted drug delivery, Aza-Michael addition; Drug delivery and release; Inverse micro emulsion; Narrow size distributions; Polyamidoamine dendrimers; Polyethylene glycol diacrylate; Structural feature; W/o microemulsions, Controlled drug delivery
International Standard Serial Number (ISSN)
Article - Journal
© 2018 American Chemical Society (ACS), All rights reserved.
14 Aug 2018