Penicillin V-Conjugated PEG-PAMAM Star Polymers
Starburst® PAMAM dendrimers are potential carriers for drug delivery due to their unique structure. Drug-delivery scaffolds were designed and built up based on the polyethylene glycolpolyamidoamine (PEG-PAMAM) star polymer. Penicillin V was used as a model carboxylic group containing drug to conjugate with full- and half-generation PAMAM dendrimers. G2.5 PAMAM (with 32 carboxylic groups on the surface) dendrimers and G3.0 (with 32 primary amine groups on the surface) were typically chosen. There are two strategies given in the paper where a drug carrying a carboxylic group (e.g. penicillin V) was coupled to star polymer via amide and ester bonds, respectively. FT-IR, UV-Vis and 1H-NMR were used to characterize the intermediates and drug-star polymer conjugates. A single-strain bacterium, Staphylococcus aureus, was grown up for penicillin-conjugated PEG-PAMAM (G3.0) star polymer activity test. The result verified the bioavailability of modified penicillin after the ester bond was cleaved.
H. Yang and S. T. Lopina, "Penicillin V-Conjugated PEG-PAMAM Star Polymers," Journal of Biomaterials Science, Polymer Edition, vol. 14, no. 10, pp. 1043-1056, Taylor & Francis, Oct 2003.
The definitive version is available at https://doi.org/10.1163/156856203769231556
Chemical and Biochemical Engineering
Keywords and Phrases
Drug-delivery system; Penicillin V; Polyamidoamine dendrimers; Polyethylene glycol; Star polymer
International Standard Serial Number (ISSN)
Article - Journal
© 2003 Taylor & Francis, All rights reserved.
01 Oct 2003