Nanomaterial-Mediated CNS Delivery of Diagnostic and Therapeutic Agents
Research into the diagnosis and treatment of central nervous system (CNS) diseases has been enhanced by rapid advances in nanotechnology and an expansion in the library of nanostructured carriers. This review discusses the latest applications of nanomaterials in the CNS with an emphasis on brain tumors. Novel administration routes and transport mechanisms for nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents to bypass or cross the blood brain barrier (BBB) are also discussed. These include temporary disruption of the BBB, use of impregnated polymers (polymer wafers), convection-enhanced delivery (CED), and intranasal delivery. Moreover, an in vitro BBB model capable of mimicking geometrical, cellular and rheological features of the human cerebrovasculature has been developed. This is a useful tool that can be used for screening CNS nanoparticles or therapeutics prior to in vivo and clinical investigation. A discussion of this novel model is included.
L. Biddlestone-Thorpe et al., "Nanomaterial-Mediated CNS Delivery of Diagnostic and Therapeutic Agents," Advanced Drug Delivery Reviews, vol. 64, no. 7, pp. 605 - 613, Elsevier B.V., May 2012.
The definitive version is available at https://doi.org/10.1016/j.addr.2011.11.014
Chemical and Biochemical Engineering
Keywords and Phrases
Blood-brain barrier (BBB); Brain cancer; Central nervous system (CNS); Convection enhanced delivery (CED); Flow-based in vitro BBB model; Nanoparticle
International Standard Serial Number (ISSN)
Article - Journal
© 2012 Elsevier B.V., All rights reserved.
15 May 2012