Title

Folate-Mediated Chemotherapy and Diagnostics: An Updated Review and Outlook

Abstract

Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Diagnosis; Folate receptor; Folic acid; Nanomedicine; Targeted delivery

International Standard Serial Number (ISSN)

0168-3659; 1873-4995

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2017 Elsevier B.V., All rights reserved.

Publication Date

28 Apr 2017

PubMed ID

28235591

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