Extended Release of a Novel Antidepressant, Venlafaxine, based on Anionic Polyamidoamine Dendrimers and Poly(Ethylene Glycol)-Containing Semi-Interpenetrating Networks
The multiple daily administration of venlafaxine, a novel third-generation antidepressant, was reduced based on polyamidoamine and polyethylene glycol (PEG)-containing semi-interpenetrating network (IPN), respectively. Venlafaxine was covalently linked to water-soluble G2.5 anionic polyamidoamine dendrimer via a hydrolyzable ester bond. Semi-IPN hydrogels were prepared by crosslinking acrylamide in the presence of PEG, and venlafaxine with predetermined amounts was loaded in situ. Dendrimer-venlafaxine conjugate and semi-IPNs were characterized by proton nuclear magnetic resonance and Fourier transform infrared, respectively. The effect of PEG concentration and molecular weight was studied and discussed for an optimal controlled release.
H. Yang and S. T. Lopina, "Extended Release of a Novel Antidepressant, Venlafaxine, based on Anionic Polyamidoamine Dendrimers and Poly(Ethylene Glycol)-Containing Semi-Interpenetrating Networks," Journal of Biomedical Materials Research - Part A, vol. 72, no. 1, pp. 107 - 114, Wiley Periodicals, Inc., Jan 2005.
The definitive version is available at https://doi.org/10.1002/jbm.a.30220
Chemical and Biochemical Engineering
Keywords and Phrases
Extended release; Polyacrylamide hydrogel; Polyamidoamine (PAMAM) dendrimer; Polyethylene glycol; Semi-interpenetrating network (IPN); StarburstÂ®; Venlafaxine
International Standard Serial Number (ISSN)
Article - Journal
© 2005 Wiley Periodicals, Inc., All rights reserved.
01 Jan 2005