Title

Electrospun Gelatin-arabinoxylan Ferulate Composite Fibers for Diabetic Chronic Wound Dressing Application

Abstract

Blends of arabinoxylan ferulate (AXF) and gelatin (GEL) at 1:1, 2:1 and 4:1 mass ratios were electrospun into composite fibrous mats as a wound-healing drug delivery platform. The composite fibers were characterized in terms of morphology, tensile properties, pore size, porosity and molecular composition. The composite fibers showed excellent cytocompatibility. Silver was impregnated into GEL-AXF nanofibers, and it was slowly released, resulting in bacterial growth inhibition as confirmed by the Kirby—Bauer disk-diffusion assay. This work establishes an electrospun arabinoxylan fibrous material platform with the potential to treat chronic diabetic wounds.

Department(s)

Chemical and Biochemical Engineering

Comments

This work was supported, in part, by the National Science Foundation (CAREER award CBET0954957).

Keywords and Phrases

Arabinoxylan; chronic wound; diabetes; electrospinning; gelatin; nanofiber; wound dressing

International Standard Serial Number (ISSN)

0091-4037; 1563-535X

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2019 Taylor & Francis, All rights reserved.

Publication Date

24 Jul 2019

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