Aza-Michael Addition Cross-Linking Strategy for Formation of Dendrimer Hydrogels, Micro/Nanogels, and Cryogels
Statement of Purpose: The multi-functionality and well-defined nanostructure makes dendrimer an ideal cross-linking building block for producing three-dimensional networks, naming dendrimer hydrogel (DH).1 The DH expands the structural diversity of dendrimer itself by cross-linking on a three-dimensional scale and greatly enriching the loading pathway as drug delivery carriers. We developed a DH platform based on aza-Michael addition cross-linking strategy and explored its application as drug delivery system.2 Following the aza-Michael addition, the nucleophilic amines on the hyperbranched polyamidoamine (PAMAM) dendrimer surface react with α, Î²-unsaturated ester of the terminal acrylate groups in linear polyethylene glycol diacrylate (PEG DA) in water to form a cross-linked network. This dendrimer-PEG DA aza-Michael addition is a green approach as it proceeds efficiently at room temperature without the use of a catalyst. We then applied the gelation process in an emulsion system and manipulate the parameters to get micro/nanogel.3 The expansion from hydrogel to microgel enriches the route of administration from intra-tumoral to intravenous. Cryogel based on the same dendritic components is developed following cryo-aza-Michael gelation. The dendrimer cryogel exhibits excellent rebound performance and does not show significant stress relaxation under cyclic.4.
J. Wang and H. Yang, "Aza-Michael Addition Cross-Linking Strategy for Formation of Dendrimer Hydrogels, Micro/Nanogels, and Cryogels," Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium, vol. 40, pp. 276-276, Society for Biomaterials, Apr 2019.
42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence (2019: Apr. 3-6, Seattle, WA)
Chemical and Biochemical Engineering
Keywords and Phrases
Addition reactions; Amines; Controlled drug delivery; Crosslinking; Emulsification; Gelation; Hydrogels; Stress analysis; Stress relaxation; Targeted drug delivery, Aza-Michael addition; Cross-linked networks; Drug delivery carrier; Drug delivery system; Linear polyethylene glycol; Polyamidoamine dendrimers; Structural diversity; Three-dimensional networks, Dendrimers
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Article - Conference proceedings
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06 Apr 2019