Dendrimers exhibit super atomistic features by virtue of their well-defined discrete quantized nanoscale structures. Here, we show that hyperbranched amine-terminated polyamidoamine (PAMAM) dendrimer G4.0 reacts with linear polyethylene glycol (PEG) diacrylate (575 g/mol) via the aza-Michael addition reaction at a subzero temperature (-20 °C), namely cryo-aza-Michael addition, to form a macroporous superelastic network, i.e., dendrimer cryogel. Dendrimer cryogels exhibit biologically relevant Young's modulus, high compression elasticity and super resilience at ambient temperature. Furthermore, the dendrimer cryogels exhibit excellent rebound performance and do not show significant stress relaxation under cyclic deformation over a wide temperature range (-80 to 100 °C). The obtained dendrimer cryogels are stable at acidic pH but degrade quickly at physiological pH through self-triggered degradation. Taken together, dendrimer cryogels represent a new class of scaffolds with properties suitable for biomedical applications.
J. Wang and H. Yang, "Superelastic and pH-Responsive Degradable Dendrimer Cryogels Prepared by Cryo-Aza-Michael Addition Reaction," Scientific Reports, vol. 8, no. 1, Nature Publishing Group, Dec 2018.
The definitive version is available at https://doi.org/10.1038/s41598-018-25456-y
Chemical and Biochemical Engineering
Keywords and Phrases
dendrimer; macrogol; PAMAM Starburst; poly(ethylene glycol)diacrylate; polyamidoamine; polyamine, chemistry; cryogel; drug therapy; elasticity; human; porosity; tissue engineering, Cryogels; Dendrimers; Elasticity; Humans; Polyamines; Polyethylene Glycols; Porosity; Tissue Engineering
International Standard Serial Number (ISSN)
Article - Journal
© 2018 The Authors, All rights reserved.
01 Dec 2018