Lyophilization in Vials on Trays: Effects of Tray Side

Abstract

The effects of tray side on the performance of lyophilization of pharmaceuticals in vials arranged in clusters of hexagonal arrays on trays are studied and the results of this work indicate that it would be beneficial to operate the freeze drying process by employing freeze dryers whose trays have no tray sides and using heat input control that runs the lyophilization process close to the melting and scorch temperature constraints during the primary and secondary drying stages, respectively.

Department(s)

Chemical and Biochemical Engineering

Keywords and Phrases

Distribution of Concentration of Bound Water; Distribution of Temperature; Drying Times; Freeze Drying in Vials; Heating Policies; Height of Tray Side; Hexagonal Arrays of Vials; Lyophilization in Vials; Velocity of Moving Sublimation Interface

International Standard Serial Number (ISSN)

0737-3937

Document Type

Article - Journal

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2005 Taylor & Francis, All rights reserved.

Publication Date

01 Jan 2005

Link to Full Text

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