Abstract
It is known that there is a correlation between a cell membrane potential and the proliferation of the cell. The high proliferation capacity of liver cells can also be attributed to its specific cell membrane potential as liver cell is recognized as one of the most depolarized of all differentiated cells. We hypothesized that this phenomenon can be emphasized by growing liver cells in conducting scaffolds that can increase the electrical communication among the cells. In this article, using tissue engineering techniques, we grew hepatocyte cells in scaffolds with various compositions. It was found that the scaffolds containing conducting polymer of poly (3,4-ethylenedioxythiophene) (PEDOT) provide the best condition for attachment and proliferation of the cells. More specifically, the blend of hyaluronan, PEDOT, and collagen (I) as dopants in gelatin- chitosan-based scaffold presented the best cell/scaffold interactions for regeneration of liver cells.
Recommended Citation
A. T. Rad et al., "Conducting Scaffolds For Liver Tissue Engineering," Journal of Biomedical Materials Research Part A, vol. 102, no. 11, pp. 4169 - 4181, Wiley, Nov 2014.
The definitive version is available at https://doi.org/10.1002/jbm.a.35080
Department(s)
Chemical and Biochemical Engineering
Publication Status
Full Access
Keywords and Phrases
Electrical signaling; Liver tissue engineering; Poly (3,4-ethylenedioxythiophene); Scaffold
International Standard Serial Number (ISSN)
1552-4965; 1549-3296
Document Type
Article - Journal
Document Version
Citation
File Type
text
Language(s)
English
Rights
© 2025 Wiley, All rights reserved.
Publication Date
01 Nov 2014
PubMed ID
24443356
