Bone Quality Test (BQT) Scores of Fingernails in Postmenopausal Patients Treated with Adjuvant Letrozole or Tamoxifen for Early Breast Cancer
Background: The relationship between nail and bone may be measurable, thus making the fingernail a potentially valuable tool for assessing bone health for women receiving treatment for breast cancer. In the BIG 1-98 Fingernail Pilot Substudy, Bone Quality Test (BQT) scores of fingernails were measured at two assessment timepoints. Methods: Thirteen eligible patients were enrolled into the substudy during their treatment with tamoxifen (four patients) or letrozole (nine patients). Two fingernails were tested and BQT scores averaged for two assessments six months apart. Results: BQT scores collected six months later (second assessment) significantly decreased compared with those at first collection (p = 0.007) regardless of treatment and prior fracture. Conclusion: The reduction of BQT scores observed in the patients of our small exploratory study during exposure to bone-altering breast cancer treatments is an incentive for larger studies using this technique. © 2009 Elsevier Ltd. All rights reserved.
Z. Sun et al., "Bone Quality Test (BQT) Scores of Fingernails in Postmenopausal Patients Treated with Adjuvant Letrozole or Tamoxifen for Early Breast Cancer," Breast, vol. 18, no. 2, pp. 84 - 88, Elsevier, Jan 2009.
The definitive version is available at https://doi.org/10.1016/j.breast.2009.01.003
Chemical and Biochemical Engineering
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01 Jan 2009