Glass polyalkenoate cements based on strontium calcium zinc silicate glasses (Zn-GPCs) and high molecular weight polyacrylic acids (PAA) (MW; 52,000-210,000) have been shown to exhibit mechanical properties and in vitro bioactivity suitable for arthroplasty applications. Unfortunately, these formulations exhibit working times and setting times which are too short for invasive surgical applications such as bone void filling and fracture fixation. In this study, Zn-GPCs were formulated using a low molecular weight PAA (MW; 12,700) and a modifying agent, trisodium citrate dihydrate (TSC), with the aim of improving the rheological properties of Zn-GPCs. These novel formulations were then compared with commercial self-setting calcium phosphate cement, Hydroset™, in terms of compressive strength, biaxial flexural strength and Young's modulus, as well as working time, setting time and injectability. The novel Zn-GPC formulations performed well, with prolonged mechanical strength (39 MPa, compression) greater than both vertebral bone (18.4 MPa) and the commercial control (14 MPa). However, working times (2 min) and rheological properties of Zn-GPCs, though improved, require further modifications prior to their use in minimally invasive surgical techniques. © 2009 Springer Science+Business Media, LLC.
O. M. Clarkin et al., "Comparison of an Experimental Bone Cement with a Commercial Control, Hydroset™," Journal of Materials Science: Materials in Medicine, vol. 20, no. 7, pp. 1563 - 1570, Springer, Jul 2009.
The definitive version is available at https://doi.org/10.1007/s10856-009-3701-9
Chemical and Biochemical Engineering
International Standard Serial Number (ISSN)
Article - Journal
© 2023 The Authors, All rights reserved.
Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
01 Jul 2009
Biochemical and Biomolecular Engineering Commons, Biomedical Devices and Instrumentation Commons