Lidocaine hydrochloride is used as an anesthetic in many clinical applications. This short communication investigates the effect of complete substitution of lidocaine hydrochloride for deionized (DI) water on the physico-chemical properties of two novel glass polyalkenoate cements. Substituting DI water with lidocaine hydrochloride resulted in cements with shorter working times but comparable setting times and mechanical properties. Fourier transform infrared spectroscopy confirmed that the setting reaction in cements containing DI water and lidocaine hydrochloride was completed within 24 h, post cement preparation and maturation. Further, it was explained that lidocaine hydrochloride binds to poly(acrylic) acid (PAA) due to electrostatic forces between the positively charged amino group of lidocaine hydrochloride and the carboxylic group of the PAA, resulting in a compact poly-complex precipitate.
P. Niranjan et al., "Injectable Glass Polyalkenoate Cements: Evaluation of their Rheological and Mechanical Properties with and Without the Incorporation of Lidocaine Hydrochloride," Biomedical Physics and Engineering Express, vol. 4, no. 2, article no. 027002, IOP Publishing, Mar 2018.
The definitive version is available at https://doi.org/10.1088/2057-1976/aa952b
Chemical and Biochemical Engineering
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01 Mar 2018