Since the first dendrimer was reported in 1978 by Fritz Vögtle, dendrimer research has grown exponentially, from synthesis to application in the past four decades. The distinct structure characteristics of dendrimers include nanoscopic size, multi-functionalized surface, high branching, cavernous interior, and so on, making dendrimers themselves ideal drug delivery vehicles. This mini review article provides a brief overview of dendrimer's history and properties and the latest developments of dendrimers as drug delivery systems. This review focuses on the latest progress in the applications of dendrimers as drug and gene carriers, including 1) active drug release strategies to dissociate drug/gene from dendrimer in response to stimuli; 2) size-adaptive and charge reversal dendrimer delivery systems that can better take advantage of the size and surface properties of dendrimer; 3) bulk and micro/nano dendrimer gel delivery systems. The recent advances in dendrimer formulations may lead to the generation of new drug and gene products and enable the development of novel combination therapies.
J. Wang et al., "Dendrimer-Based Drug Delivery Systems: History, Challenges, and Latest Developments," Journal of Biological Engineering, vol. 16, no. 1, article no. 18, BioMed Central, Dec 2022.
The definitive version is available at https://doi.org/10.1186/s13036-022-00298-5
Chemical and Biochemical Engineering
Keywords and Phrases
Dendrimer; Dendrimer Hydrogel; Drug Delivery; Microgel; Nanogel
International Standard Serial Number (ISSN)
Article - Journal
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Creative Commons Licensing
This work is licensed under a Creative Commons Attribution 4.0 License.
01 Dec 2022
Juan Wang was supported by the Fundamental Research Funds for the Central Universities of China (Grant No. 20822041D4094, 1082204112665) and the National Natural Science Foundation of China (52103177).