Dynamic Simulation of a Nanorod and a Polymer Molecule in a Microfluidic Device with a Complex Geometry
Department
Chemical and Biochemical Engineering
Major
Chemical Engineering
Research Advisor
Park, Joontaek
Advisor's Department
Chemical and Biochemical Engineering
Funding Source
OURE
Abstract
Separation of biomolecules and biopolymers through various microfluidic devices has been an area of research that has been under development for its uses in drug delivery and biomolecule behavior. Commercial software is not able to model the intricate dynamics of non-spherical irregular shaped particles, such as a nanorod or a polymer molecule, within these microfluidic devices. The use of COMSOL Multiphysics overcomes these difficulties. A bead-spring model is used to model the polymer molecule and a rigid dumbbell model is used to model a nanorod. The microfluidic device used to model the molecule dynamics is a well in a channel (similar to a dip in a blood vessel). Length of the polymer was varied to study the effect this had on elution time.
Biography
Meyyammai Palaniappan is a senior studying Chemical Engineering and is pursuing minors in Chemistry and Biomedical Engineering. Meyyammai is a member and former president of Missouri S&T iGEM design team. She is also a member of SWE, AiChE, and Missouri S&T’s Honor Academy.
Research Category
Engineering
Presentation Type
Oral Presentation
Document Type
Presentation
Award
Engineering oral presentation, Third place
Location
Missouri Room
Presentation Date
11 Apr 2017, 11:30 am - 12:00 pm
Dynamic Simulation of a Nanorod and a Polymer Molecule in a Microfluidic Device with a Complex Geometry
Missouri Room
Separation of biomolecules and biopolymers through various microfluidic devices has been an area of research that has been under development for its uses in drug delivery and biomolecule behavior. Commercial software is not able to model the intricate dynamics of non-spherical irregular shaped particles, such as a nanorod or a polymer molecule, within these microfluidic devices. The use of COMSOL Multiphysics overcomes these difficulties. A bead-spring model is used to model the polymer molecule and a rigid dumbbell model is used to model a nanorod. The microfluidic device used to model the molecule dynamics is a well in a channel (similar to a dip in a blood vessel). Length of the polymer was varied to study the effect this had on elution time.
