Aerogels as Drug Delivery Systems: Silica and Dysprosia Aerogels as Drug Carriers for Indomethacin and Paracetamol
Department
Chemistry
Major
Chemistry
Research Advisor
Sotiriou-Leventis, Lia
Advisor's Department
Chemistry
Funding Source
Missouri S&T Opportunities for Undergraduate Research Experiences (OURE) Program; ARO and NSF
Abstract
The use of aerogels as drug delivery systems is fast growing as an attractive field of research because of their high surface area and low density. This project is on the feasibility of a system of aerogels and pharmaceutical drugs combined in a novel way. Two drugs were investigated: paracetamol and indomethacin; and two biocompatible aerogels (silica and dysprosia based) were loaded with the aforementioned drugs. We found that silica aerogels could be loaded with 13.6% paracetamol and 12.1% indomethacin, while polymer crosslinked dysprosium oxide (X-DyOx) aerogels could be loaded with 35.1% paracetamol and 32.2% indomethacin. We then time-released the drugs from each aerogel in two buffer systems (0.1 N HCl and phosphate pH = 7.4). The silica aerogels showed a total drug release in 0.5 h in each system. However, XDyOx completely released paracetamol in 60 h in 0.1 N HCl and 65 h in the phosphate buffer.
Biography
Brice is a current junior in Chemistry at Missouri University of Science and Technology in Rolla, MO. He has worked under the guidance of Dr. Chariklia Sotiriou-Leventis on aerogel systems and pharmaceutical applications since January 2010. He plans on attending graduate school and pursuing further research opportunities after graduation.
Research Category
Sciences
Presentation Type
Poster Presentation
Document Type
Poster
Location
Upper Atrium/Hallway
Presentation Date
06 Apr 2011, 9:00 am - 11:45 am
Aerogels as Drug Delivery Systems: Silica and Dysprosia Aerogels as Drug Carriers for Indomethacin and Paracetamol
Upper Atrium/Hallway
The use of aerogels as drug delivery systems is fast growing as an attractive field of research because of their high surface area and low density. This project is on the feasibility of a system of aerogels and pharmaceutical drugs combined in a novel way. Two drugs were investigated: paracetamol and indomethacin; and two biocompatible aerogels (silica and dysprosia based) were loaded with the aforementioned drugs. We found that silica aerogels could be loaded with 13.6% paracetamol and 12.1% indomethacin, while polymer crosslinked dysprosium oxide (X-DyOx) aerogels could be loaded with 35.1% paracetamol and 32.2% indomethacin. We then time-released the drugs from each aerogel in two buffer systems (0.1 N HCl and phosphate pH = 7.4). The silica aerogels showed a total drug release in 0.5 h in each system. However, XDyOx completely released paracetamol in 60 h in 0.1 N HCl and 65 h in the phosphate buffer.
