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| Title: | Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC) |
| Author (s): | Ates, Burhan Abraham, Linu Sara Ercal, Nuran |
| Department/Lab Affiliations: | Center for Environmental Science and Technology (CEST) Chemistry Environmental Research Center |
| Keywords: | NAC NACA antioxidant properties radical scavenging |
| Issue Date: | 2008 |
| Publisher: | Taylor & Francis |
| Citation: | Ates B Abraham LS, Ercal N In vitro Antioxidant and Free-Radical Scavenging Properties of N-Acetylcysteine Amide: A Novel Thiol Antioxidant, Free Radical Research, Vol. 42(4), 2008, pp. 372-377, 2008. |
| Abstract: | The antioxidant potential of N-acetylcysteine amide (NACA), also known as AD4, was assessed by employing different in vitro assays. These included reducing power, free radical scavenging capacities, peroxidation inhibiting activity through linoleic acid emulsion system and metal chelating capacity, as compared to NAC and three widely used antioxidants, agr-tocopherol, ascorbic acid and butylated hydroxytoluene (BHT). Of the antioxidant properties that were investigated, NACA was shown to possess higher 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging ability and reducing power than NAC, at all the concentrations, whereas the scavenging ability of H2O2 differed with concentration. While NACA had greater H2O2 scavenging capacity at the highest concentration, NAC was better than NACA at lower concentrations. NAC and NACA had a 60% and 55% higher ability to prevent β-carotene bleaching, respectively, as compared to control. The chelating activity of NACA was more than 50% that of the metal chelating capacity of EDTA and four and nine times that of BHT and agr-tocopherol, respectively. When compared to NACA and NAC; agr-tocopherol had higher DPPH scavenging abilities and BHT and agr-tocopherol had better β-carotene bleaching power. These findings provide evidence that the novel antioxidant, NACA, has indeed enhanced the antioxidant properties of NAC. |
| Type: | Article - Journal text |
| Copyright Notice: | Pre-print: author can archive; Post-print: author can archive with restrictions;Restriction: 12 month embargo for STM Journals;18 month embargo for SSH journals; Conditions: Some individual journals may have policies prohibiting pre-print archiving;Publisher's version/PDF cannot be used;On a non-profit server;Published source must be acknowledged;Must link to publisher version; This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. FULL COPYRIGHT INFORMATION: |
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| Link to this page: |
| title | Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC) |
| contributor.author | Ates, Burhan |
| contributor.author | Abraham, Linu Sara |
| contributor.author | Ercal, Nuran |
| contributor.deptlab | Center for Environmental Science and Technology (CEST) |
| contributor.deptlab | Chemistry |
| contributor.deptlab | Environmental Research Center |
| subject | NAC |
| subject | NACA |
| subject | antioxidant properties |
| subject | radical scavenging |
| date.issued | 2008 |
| publisher | Taylor & Francis |
| identifier.citation | Ates B Abraham LS, Ercal N In vitro Antioxidant and Free-Radical Scavenging Properties of N-Acetylcysteine Amide: A Novel Thiol Antioxidant, Free Radical Research, Vol. 42(4), 2008, pp. 372-377, 2008. |
| identifier.pub.URI | |
| description.abstract | The antioxidant potential of N-acetylcysteine amide (NACA), also known as AD4, was assessed by employing different in vitro assays. These included reducing power, free radical scavenging capacities, peroxidation inhibiting activity through linoleic acid emulsion system and metal chelating capacity, as compared to NAC and three widely used antioxidants, agr-tocopherol, ascorbic acid and butylated hydroxytoluene (BHT). Of the antioxidant properties that were investigated, NACA was shown to possess higher 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) radical scavenging ability and reducing power than NAC, at all the concentrations, whereas the scavenging ability of H2O2 differed with concentration. While NACA had greater H2O2 scavenging capacity at the highest concentration, NAC was better than NACA at lower concentrations. NAC and NACA had a 60% and 55% higher ability to prevent β-carotene bleaching, respectively, as compared to control. The chelating activity of NACA was more than 50% that of the metal chelating capacity of EDTA and four and nine times that of BHT and agr-tocopherol, respectively. When compared to NACA and NAC; agr-tocopherol had higher DPPH scavenging abilities and BHT and agr-tocopherol had better β-carotene bleaching power. These findings provide evidence that the novel antioxidant, NACA, has indeed enhanced the antioxidant properties of NAC. |
| type | Article - Journal |
| type.DCMIType | text |
| type.status | Postprint |
| rights | Pre-print: author can archive; Post-print: author can archive with restrictions;Restriction: 12 month embargo for STM Journals;18 month embargo for SSH journals; Conditions: Some individual journals may have policies prohibiting pre-print archiving;Publisher's version/PDF cannot be used;On a non-profit server;Published source must be acknowledged;Must link to publisher version; |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. |
| rights.URI | |
| date.available | 2008-06-13T15:04:23Z |
| identifier.persist.URI |