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| Title: | Freeze casting of porous hydroxyapatite scaffolds – II Sintering, microstructure, and mechanical behavior |
| Author (s): | Fu, Qiang Rahaman, Mohamed Dogan, Fatih Bal, B. Sonny |
| Department/Lab Affiliations: | Energy Research and Development Center Materials Research Center Materials Science & Engineering University Transportation Center Virtual Reality & Rapid Prototyping Lab |
| Keywords: | biomaterials freeze casting hydroxyapatite mechanical behavior scaffolds |
| Issue Date: | 2008-03-13 |
| Publisher: | John Wiley & Sons |
| Citation: | Fu, Qiang., Rahaman, Mohamed N., Dogan, Fatih., and Bal, B. Sonny. "Freeze Casting of Porous Hydroxyapatite Scaffolds – II Sintering, Microstructure, and Mechanical Behavior.", Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 86B, no. 2, 2008. |
| Abstract: | In Part I, the influence of processing parameters on the general microstructure of freeze-cast hydroxyapatite (HA) constructs was explored. This work is an extension of Part I to investigate the effect of sintering conditions on the microstructure and mechanical behavior of freeze-cast HA. For constructs prepared from aqueous suspensions (5-20 vol % HA), sintering for 3 h at temperatures from 1250°C to 1375°C produced a decrease in porosity of <5% but an increase in strength of nearly 50%. Constructs with a porosity of 52% had compressive strengths of 12 ± 1 MPa and 5 ± 1 MPa in the directions parallel and perpendicular to the freezing direction, respectively. The mechanical response showed high strain tolerance (5-10% at the maximum stress), high strain to failure (>20%), and high strain rate sensitivity. Manipulation of the freeze-cast microstructure, achieved by additions of glycerol and 1,4-dioxane to the aqueous suspensions, produced changes in the magnitude of the mechanical response, but little change in the general nature of the response. The favorable mechanical behavior of the porous constructs, coupled with the ability to modify their microstructure, indicates the potential of the present freeze-casting route for the production of porous scaffolds for bone tissue engineering. |
| Type: | Article - Journal text |
| In Title: | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
| Copyright Notice: | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. Pre-print: author can archive; Post-print: author can archive; FULL COPYRIGHT INFORMATION: |
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| title | Freeze casting of porous hydroxyapatite scaffolds – II Sintering, microstructure, and mechanical behavior |
| contributor.author | Fu, Qiang |
| contributor.author | Rahaman, Mohamed |
| contributor.author | Dogan, Fatih |
| contributor.author | Bal, B. Sonny |
| contributor.deptlab | Energy Research and Development Center |
| contributor.deptlab | Materials Research Center |
| contributor.deptlab | Materials Science & Engineering |
| contributor.deptlab | University Transportation Center |
| contributor.deptlab | Virtual Reality & Rapid Prototyping Lab |
| subject | biomaterials |
| subject | freeze casting |
| subject | hydroxyapatite |
| subject | mechanical behavior |
| subject | scaffolds |
| date.issued | 2008-03-13 |
| publisher | John Wiley & Sons |
| identifier.citation | Fu, Qiang., Rahaman, Mohamed N., Dogan, Fatih., and Bal, B. Sonny. "Freeze Casting of Porous Hydroxyapatite Scaffolds – II Sintering, Microstructure, and Mechanical Behavior.", Journal of Biomedical Materials Research Part B: Applied Biomaterials, vol. 86B, no. 2, 2008. |
| identifier.pub.URI | |
| description.abstract | In Part I, the influence of processing parameters on the general microstructure of freeze-cast hydroxyapatite (HA) constructs was explored. This work is an extension of Part I to investigate the effect of sintering conditions on the microstructure and mechanical behavior of freeze-cast HA. For constructs prepared from aqueous suspensions (5-20 vol % HA), sintering for 3 h at temperatures from 1250°C to 1375°C produced a decrease in porosity of <5% but an increase in strength of nearly 50%. Constructs with a porosity of 52% had compressive strengths of 12 ± 1 MPa and 5 ± 1 MPa in the directions parallel and perpendicular to the freezing direction, respectively. The mechanical response showed high strain tolerance (5-10% at the maximum stress), high strain to failure (>20%), and high strain rate sensitivity. Manipulation of the freeze-cast microstructure, achieved by additions of glycerol and 1,4-dioxane to the aqueous suspensions, produced changes in the magnitude of the mechanical response, but little change in the general nature of the response. The favorable mechanical behavior of the porous constructs, coupled with the ability to modify their microstructure, indicates the potential of the present freeze-casting route for the production of porous scaffolds for bone tissue engineering. |
| type | Article - Journal |
| type.DCMIType | text |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. |
| rights | Pre-print: author can archive; Post-print: author can archive; |
| rights.URI | |
| rights.URI | |
| relation.isPartOf | Journal of Biomedical Materials Research Part B: Applied Biomaterials |
| date.available | 2008-08-06T21:26:59Z |
| identifier.persist.URI |