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| Title: | Determination of ozonation rate constants for lincomycin and spectinomycin |
| Author (s): | Qiang, Z. Adams, Craig D. Surampalli, Rao Y |
| Department/Lab Affiliations: | Civil, Architectural & Environmental Engineering Environmental Research Center |
| Keywords: | Rate Constants. Spectinomycin. Stopped-Flow Spectrophotometry. |
| Subject Terms: | Antibiotics. Lincomycin. Ozone. |
| Issue Date: | 2004 |
| Publisher: | Taylor & Francis |
| Citation: | Qiang, Z., Adams, C., Surampalli, R. (2004) “Determination of Ozonation Rate Constants for Lincomycin and Spectinomycin,” Ozone Science and Engineering, 26, 535-537. |
| Abstract: | Recent occurrences of pharmaceutical antibiotics in surface water, drinking water, and wastewater systems have gained significant attention due to their potential threats to human health. This study determined the absolute second-order rate constants of ozone with two amine-based antibiotics, namely, lincomycin and spectinomycin, using the stopped-flow technique under controlled ionic strength, buffer, and temperature. Results indicate that ozone reacts quickly with the selected antibiotics, and the reaction rate significantly depends on solution pH. For lincomycin, ozone attacks its free amine group and sulfur group with absolute rate constants of 2.76 × 106 M-1·s-1 (for neutral form) and 3.26 × 105 M-1·s-1 (for monoprotonated form), respectively. For spectinomycin, ozone attacks two free amine groups with absolute rate constants of 1.27 × 106 M-1·s-1 (for neutral form) and 3.30 × 105 M-1·s-1 (for monoprotonated form), respectively. These rate constants have been corrected to zero ionic strength. Protonated amine is nonreactive toward ozone. Model prediction indicates that lincomycin and spectinomycin can be effectively transformed by ozonation processes around neutral pH. |
| Type: | Article - Journal text |
| Copyright Notice: | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. FULL COPYRIGHT INFORMATION: |
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| title | Determination of ozonation rate constants for lincomycin and spectinomycin |
| contributor.author | Qiang, Z. |
| contributor.author | Adams, Craig D. |
| contributor.author | Surampalli, Rao Y |
| contributor.deptlab | Civil, Architectural & Environmental Engineering |
| contributor.deptlab | Environmental Research Center |
| contributor.sponsor | Environmental Protection Agency |
| subject | Rate Constants. |
| subject | Spectinomycin. |
| subject | Stopped-Flow Spectrophotometry. |
| subject.LCSH | Antibiotics. |
| subject.LCSH | Lincomycin. |
| subject.LCSH | Ozone. |
| date.issued | 2004 |
| publisher | Taylor & Francis |
| identifier.citation | Qiang, Z., Adams, C., Surampalli, R. (2004) “Determination of Ozonation Rate Constants for Lincomycin and Spectinomycin,” Ozone Science and Engineering, 26, 535-537. |
| identifier.pub.URI | |
| description.abstract | Recent occurrences of pharmaceutical antibiotics in surface water, drinking water, and wastewater systems have gained significant attention due to their potential threats to human health. This study determined the absolute second-order rate constants of ozone with two amine-based antibiotics, namely, lincomycin and spectinomycin, using the stopped-flow technique under controlled ionic strength, buffer, and temperature. Results indicate that ozone reacts quickly with the selected antibiotics, and the reaction rate significantly depends on solution pH. For lincomycin, ozone attacks its free amine group and sulfur group with absolute rate constants of 2.76 × 106 M-1·s-1 (for neutral form) and 3.26 × 105 M-1·s-1 (for monoprotonated form), respectively. For spectinomycin, ozone attacks two free amine groups with absolute rate constants of 1.27 × 106 M-1·s-1 (for neutral form) and 3.30 × 105 M-1·s-1 (for monoprotonated form), respectively. These rate constants have been corrected to zero ionic strength. Protonated amine is nonreactive toward ozone. Model prediction indicates that lincomycin and spectinomycin can be effectively transformed by ozonation processes around neutral pH. |
| type | Article - Journal |
| type.DCMIType | text |
| type.status | Final version |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. |
| rights.URI | |
| date.accessioned | 2007-04-11T17:00:48Z |
| date.available | 2007-12-12T23:26:36Z |
| identifier.persist.URI |