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| Title: | Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone |
| Author (s): | Afrasiabi Navan, Zahra Fok, Jansina Mehta, Kapil Padhye, Subhash B Rath, Nigam Sinn, Ekk |
| Department/Lab Affiliations: | Chemistry Physics |
| Keywords: | Anti tumor metallothiosemicarbazonates Palladium complex Phenanthrenequinone thiosemicarbazone |
| Subject Terms: | Apoptosis. |
| Issue Date: | 2005 |
| Publisher: | American Chemical Society |
| Citation: | Padhye, S.B., Afrasiabi, Z., Sinn, E., Fok, J., Mehta, K., and Rath, N. "Antitumor Metallothiosemicarbazonates: Structure and Antitumor Activity of Palladium Complex of Phenanthrenequinone Thiosemicarbazone." Inorganic Chemistry, vol. 44, no. 5, (2005). |
| Abstract: | The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death. |
| Type: | Article - Journal text |
| In Title: | Inorganic Chemistry |
| Copyright Notice: | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. FULL COPYRIGHT INFORMATION: |
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| title | Antitumor metallothiosemicarbazonates: structure and antitumor activity of palladium complex of phenanthrenequinone thiosemicarbazone |
| contributor.author | Afrasiabi Navan, Zahra |
| contributor.author | Fok, Jansina |
| contributor.author | Mehta, Kapil |
| contributor.author | Padhye, Subhash B |
| contributor.author | Rath, Nigam |
| contributor.author | Sinn, Ekk |
| contributor.deptlab | Chemistry |
| contributor.deptlab | Physics |
| subject | Anti tumor metallothiosemicarbazonates |
| subject | Palladium complex |
| subject | Phenanthrenequinone thiosemicarbazone |
| subject.LCSH | Apoptosis. |
| date.issued | 2005 |
| publisher | American Chemical Society |
| identifier.citation | Padhye, S.B., Afrasiabi, Z., Sinn, E., Fok, J., Mehta, K., and Rath, N. "Antitumor Metallothiosemicarbazonates: Structure and Antitumor Activity of Palladium Complex of Phenanthrenequinone Thiosemicarbazone." Inorganic Chemistry, vol. 44, no. 5, (2005). |
| identifier.pub.URI | |
| description.abstract | The crystal structure of the potential antitumor metal compound, viz. chloro, mono(phenanthrenequinone thiosemicarbazonato) palladium(II) dimethyl formamide solvate, is reported. The central palladium(II) atom is in a square planar environment provided by the tridentate, monoanionic thiosemicarbazone ligand and the ancillary chloride ion. The compound exhibited remarkable activity against drug-sensitive and drug-resistant breast cancer cell lines and was relatively nontoxic toward the normal mammary epithelial cells. The drug-induced killing effect against breast cancer cell lines was predominantly mediated via apoptosis, a physiologic form of cell death. |
| type | Article - Journal |
| type.DCMIType | text |
| type.status | Final version |
| relation.isPartOf | Inorganic Chemistry |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. |
| rights.URI | |
| date.accessioned | 2007-04-11T17:00:48Z |
| date.available | 2008-04-02T19:06:16Z |
| identifier.persist.URI |