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| Title: | Alternative splicing: associating frequency with isoforms | |
| Author (s): | Roy, Anuradha Leopold, Jennifer Maglia, Anne | |
| Department/Lab Affiliations: | Computer Science | |
| Keywords: | Alternative Splicing Isoforms pre-mRNA protein frequency | |
| Issue Date: | 2007-10-17 | |
| Publisher: | IEEE | |
| Citation: | Roy, Anuradha., Leoppold, Jennifer., and Maglia, Anne M. "Alternative Splicing: Associating Frequency with Isoforms." IEEE 7th International Symposium on Bioinformatics and Bioengineering, (2007). | |
| Abstract: | In the simplest model of protein production, a gene gives rise to a single protein; DNA is transcribed to form pre-mRNA, which is converted to mRNA by splicing or removing introns. The result is a chain of exons that is translated to form a protein. Alternative splicing of exons may result in the formation of multiple proteins from the same gene sequence. However, not all of these proteins may be functional. Thus, we ask whether we can predict and rank (in order of frequency of occurrence and functional importance) the set of possible proteins for a gene. Herein we describe a tool that predicts the relative frequencies of isoforms that can be produced from a given gene. | |
| Type: | Article - Journal text | |
| In Title: | IEEE 7th International Symposium on Bioinformatics and Bioengineering | |
| Copyright Notice: | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. FULL COPYRIGHT INFORMATION: | |
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| title | Alternative splicing: associating frequency with isoforms | |
| contributor.author | Roy, Anuradha | |
| contributor.author | Leopold, Jennifer | |
| contributor.author | Maglia, Anne | |
| contributor.deptlab | Computer Science | |
| subject | Alternative Splicing | |
| subject | Isoforms | |
| subject | pre-mRNA | |
| subject | protein frequency | |
| date.issued | 2007-10-17 | |
| publisher | IEEE | |
| identifier.citation | Roy, Anuradha., Leoppold, Jennifer., and Maglia, Anne M. "Alternative Splicing: Associating Frequency with Isoforms." IEEE 7th International Symposium on Bioinformatics and Bioengineering, (2007). | |
| identifier.pub.URI | ||
| description.abstract | In the simplest model of protein production, a gene gives rise to a single protein; DNA is transcribed to form pre-mRNA, which is converted to mRNA by splicing or removing introns. The result is a chain of exons that is translated to form a protein. Alternative splicing of exons may result in the formation of multiple proteins from the same gene sequence. However, not all of these proteins may be functional. Thus, we ask whether we can predict and rank (in order of frequency of occurrence and functional importance) the set of possible proteins for a gene. Herein we describe a tool that predicts the relative frequencies of isoforms that can be produced from a given gene. | |
| type | Article - Journal | |
| type.DCMIType | text | |
| type.status | Final version | |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. | |
| rights.URI | ||
| relation.isPartOf | IEEE 7th International Symposium on Bioinformatics and Bioengineering | |
| date.accessioned | 2008-04-08T18:45:37Z | |
| date.available | 2008-04-08T18:45:39Z | |
| identifier.persist.URI | ||
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