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| Title: | Glucose oxidase (GOD)-coupled amperometric microsensor with integrated electrochemical actuation system | |
| Author (s): | Jongwon Park Kim, Chang-Soo Shanrui Zhang Choi, Minsu | |
| Department/Lab Affiliations: | Biological Sciences Electrical and Computer Engineering Intelligent Microsystem Laboratory | |
| Keywords: | Actuator GOD(Glucose oxidase) Glucose measurement Solid-state biosensor thin-lm amperometric sensor | |
| Issue Date: | 2005 | |
| Publisher: | Institute of Electrical and Electronics Engineers | |
| Citation: | Jongwon Park; Chang-Soo Kim; Shanrui Zhang; Minsu Choi, "Glucose Oxidase (GOD)-Coupled Amperometric Microsensor with Integrated Electrochemical Actuation System" IMTC 2005. Proceedings of the IEEE Instrumentation and Measurement Technology Conference, 2005. vol.1, pp. 134- 138, 16-19 May 2005 | |
| Abstract: | Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue, a novel solid-state glucose oxidase-coupled amperometric biosensor with integrated electrochemical actuation system has been designed and validated. There are two key components of the proposed glucose biosensor: solid-state GOD-coupled thin-lm amperometric sensing element andO 2 depleting/saturating built-in electrochemical actuator. The actuator can be used to accomplish in-situ 1-point self-calibration by depleting O 2 (i.e., by simulating glucose-free environment). Also, it can be used at the same time to extend the proposed sensor''s linear detection range by in ating O 2 (i.e., by enhancing glucose sensitivity). A prototype sensor was fabricated and a series of lab experiments was conducted. Collected data assures that the proposed sensor effectively establishes the zero calibration point and signi cantly enhances its measurement sensitivity and con dence. | |
| Type: | Article - Conference proceedings text | |
| Copyright Notice: | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. FULL COPYRIGHT INFORMATION: | |
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| title | Glucose oxidase (GOD)-coupled amperometric microsensor with integrated electrochemical actuation system | |
| contributor.author | Jongwon Park | |
| contributor.author | Kim, Chang-Soo | |
| contributor.author | Shanrui Zhang | |
| contributor.author | Choi, Minsu | |
| contributor.deptlab | Biological Sciences | |
| contributor.deptlab | Electrical and Computer Engineering | |
| contributor.deptlab | Intelligent Microsystem Laboratory | |
| subject | Actuator | |
| subject | GOD(Glucose oxidase) | |
| subject | Glucose measurement | |
| subject | Solid-state biosensor | |
| subject | thin-lm amperometric sensor | |
| date.issued | 2005 | |
| date.submitted | 2007 | |
| publisher | Institute of Electrical and Electronics Engineers | |
| identifier.citation | Jongwon Park; Chang-Soo Kim; Shanrui Zhang; Minsu Choi, "Glucose Oxidase (GOD)-Coupled Amperometric Microsensor with Integrated Electrochemical Actuation System" IMTC 2005. Proceedings of the IEEE Instrumentation and Measurement Technology Conference, 2005. vol.1, pp. 134- 138, 16-19 May 2005 | |
| identifier.pub.URI | ||
| description.abstract | Recent developments for biosensors have been mainly focused on miniaturization and exploratory use of new materials. It should be emphasized that the absence of a novel "in-situ self-calibration/diagnosis technique" that is not connected to an external apparatus is a key obstacle to the realization of a biosensor for continuous use with minimum attendance. In order to address this issue, a novel solid-state glucose oxidase-coupled amperometric biosensor with integrated electrochemical actuation system has been designed and validated. There are two key components of the proposed glucose biosensor: solid-state GOD-coupled thin-lm amperometric sensing element andO 2 depleting/saturating built-in electrochemical actuator. The actuator can be used to accomplish in-situ 1-point self-calibration by depleting O 2 (i.e., by simulating glucose-free environment). Also, it can be used at the same time to extend the proposed sensor''s linear detection range by in ating O 2 (i.e., by enhancing glucose sensitivity). A prototype sensor was fabricated and a series of lab experiments was conducted. Collected data assures that the proposed sensor effectively establishes the zero calibration point and signi cantly enhances its measurement sensitivity and con dence. | |
| type | Article - Conference proceedings | |
| type.DCMIType | text | |
| type.status | Final version | |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. | |
| rights.URI | ||
| date.accessioned | 2007-04-05T14:26:23Z | |
| date.available | 2007-04-05T14:26:23Z | |
| identifier.persist.URI | ||
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