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| Title: | Data-driven homologue matching for chromosome identification | |
| Author (s): | Stanley, R. Joe Keller, J.M. Gader, P. Caldwell, C.W. | |
| Department/Lab Affiliations: | Electrical and Computer Engineering Image Processing Laboratory | |
| Keywords: | autosomal classes biology computing cellular biophysics chromosome identification data-driven homologue matching dynamic programming genetics human metaphase spreads image analysis techniques karyotyping medical image processing metaphase spread neural nets normal chromosomes numerical aberrations detection optical images structural abnormalities | |
| Issue Date: | 1998 | |
| Publisher: | Institute of Electrical and Electronics Engineers | |
| Citation: | Stanley, R.J.; Keller, J.M.; Gader, P.; Caldwell, C.W., "Data-driven homologue matching for chromosome identification," IEEE Transactions on Medical Imaging, vol.17, no.3 pp.451-462, Jun 1998 | |
| Abstract: | Karyotyping involves the visualization and classification of chromosomes into standard classes. In "normal" human metaphase spreads, chromosomes occur in homologous pairs for the autosomal classes 1-22, and X chromosome for females. Many existing approaches for performing automated human chromosome image analysis presuppose cell normalcy, containing 46 chromosomes within a metaphase spread with two chromosomes per class. This is an acceptable assumption for routine automated chromosome image analysis. However, many genetic abnormalities are directly linked to structural or numerical aberrations of chromosomes within the metaphase spread. Thus, two chromosomes per class cannot be assumed for anomaly analysis. This paper presents the development of image analysis techniques which are extendible to detecting numerical aberrations evolving from structural abnormalities. Specifically, an approach to identifying "normal" chromosomes from selected class(es) within a metaphase spread is presented. Chromosome assignment to a specific class is initially based on neural networks, followed by banding pattern and centromeric index criteria checking, and concluding with homologue matching. Experimental results are presented comparing neural networks as the sole classifier to the authors'' homologue matcher for identifying class 17 within normal and abnormal metaphase spreads. | |
| Type: | Article - Journal text | |
| Copyright Notice: | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. FULL COPYRIGHT INFORMATION: | |
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| title | Data-driven homologue matching for chromosome identification | |
| contributor.author | Stanley, R. Joe | |
| contributor.author | Keller, J.M. | |
| contributor.author | Gader, P. | |
| contributor.author | Caldwell, C.W. | |
| contributor.deptlab | Electrical and Computer Engineering | |
| contributor.deptlab | Image Processing Laboratory | |
| subject | autosomal classes | |
| subject | biology computing | |
| subject | cellular biophysics | |
| subject | chromosome identification | |
| subject | data-driven homologue matching | |
| subject | dynamic programming | |
| subject | genetics | |
| subject | human metaphase spreads | |
| subject | image analysis techniques | |
| subject | karyotyping | |
| subject | medical image processing | |
| subject | metaphase spread | |
| subject | neural nets | |
| subject | normal chromosomes | |
| subject | numerical aberrations detection | |
| subject | optical images | |
| subject | structural abnormalities | |
| date.issued | 1998 | |
| date.submitted | 2007 | |
| publisher | Institute of Electrical and Electronics Engineers | |
| identifier.citation | Stanley, R.J.; Keller, J.M.; Gader, P.; Caldwell, C.W., "Data-driven homologue matching for chromosome identification," IEEE Transactions on Medical Imaging, vol.17, no.3 pp.451-462, Jun 1998 | |
| identifier.issn | 0278-0062 | |
| identifier.pub.URI | ||
| description.abstract | Karyotyping involves the visualization and classification of chromosomes into standard classes. In "normal" human metaphase spreads, chromosomes occur in homologous pairs for the autosomal classes 1-22, and X chromosome for females. Many existing approaches for performing automated human chromosome image analysis presuppose cell normalcy, containing 46 chromosomes within a metaphase spread with two chromosomes per class. This is an acceptable assumption for routine automated chromosome image analysis. However, many genetic abnormalities are directly linked to structural or numerical aberrations of chromosomes within the metaphase spread. Thus, two chromosomes per class cannot be assumed for anomaly analysis. This paper presents the development of image analysis techniques which are extendible to detecting numerical aberrations evolving from structural abnormalities. Specifically, an approach to identifying "normal" chromosomes from selected class(es) within a metaphase spread is presented. Chromosome assignment to a specific class is initially based on neural networks, followed by banding pattern and centromeric index criteria checking, and concluding with homologue matching. Experimental results are presented comparing neural networks as the sole classifier to the authors'' homologue matcher for identifying class 17 within normal and abnormal metaphase spreads. | |
| type | Article - Journal | |
| type.DCMIType | text | |
| type.status | Final version | |
| rights | This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder. | |
| rights.URI | ||
| date.accessioned | 2007-04-05T14:04:19Z | |
| date.available | 2007-04-05T14:04:19Z | |
| identifier.persist.URI | ||
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