Bone Regeneration in Strong Porous Bioactive Glass (13-93) Scaffolds with an Oriented Microstructure Implanted in Rat Calvarial Defects
Wagner, W. R.
There is a need for synthetic bone graft substitutes to repair large bone defects resulting from trauma, malignancy and congenital diseases. Bioactive glass has attractive properties as a scaffold material but factors that influence its ability to regenerate bone in vivo are not well understood. In the present work, the ability of strong porous scaffolds of 13-93 bioactive glass with an oriented microstructure to regenerate bone was evaluated in vivo using a rat calvarial defect model. Scaffolds with an oriented microstructure of columnar pores (porosity = 50%; pore diameter = 50−150 μm) showed mostly osteoconductive bone regeneration, and new bone formation, normalized to the available pore area (volume) of the scaffolds, increased from 37% at 12 weeks to 55% at 24 weeks. Scaffolds of the same glass with a trabecular microstructure (porosity = 80%; pore width = 100−500 μm), used as the positive control, showed bone regeneration in the pores of 25% and 46% at 12 and 24 weeks, respectively. The brittle mechanical response of the as-fabricated scaffolds changed markedly to an elastoplastic response in vivo at both implantation times. These results indicate that both groups of 13-93 bioactive glass scaffolds could potentially be used to repair large bone defects, but scaffolds with the oriented microstructure could also be considered for the repair of loaded bone.
X. Liu et al., "Bone Regeneration in Strong Porous Bioactive Glass (13-93) Scaffolds with an Oriented Microstructure Implanted in Rat Calvarial Defects," Acta Biomaterialia, vol. 9, no. 1, pp. 4889-4898, Elsevier, Jan 2013.
The definitive version is available at http://dx.doi.org/10.1016/j.actbio.2012.08.029
Mining and Nuclear Engineering
Materials Science and Engineering
Keywords and Phrases
Bone Regeneration; Bioactive Glass Scaffold; Rat Calvarial Defect Model; Mineralization; Mechanical Response
Article - Journal
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