Preparation and Properties of Radioactive Rhenium Glass Microspheres Intended for in Vivo Radioembolization Therapy
Rhenium glass microspheres composed of metallic rhenium particles dispersed within a magnesium alumino borate glass matrix were produced by sintering ReO2 powder and glass frit at 1050°C. The in vitro chemical durability of radioactive and nonradioactive microspheres was determined from chemical corrosion tests on microspheres immersed in phosphate-buffered saline (PBS) solution at 37°C. The dosimetric properties of these microspheres also were calculated. The rhenium glass microspheres are chemically durable in body fluids and release < 1.2% of radioactive rhenium after being immersed in PBS solution for 32 days at 37°C. Therapeutic radioactive rhenium activities can be obtained in < 10 h by neutron activation of these microspheres in a thermal neutron flux of 8 × 1013 cm-2s-1. A 50 mg injection of radioactive rhenium glass microspheres containing 3.7 GBq of 186Re and 8.5 GBq of 188Re could deliver a 100 Gy dose to a cancerous liver while limiting the total body dose from rhenium dissolution in vivo to approximately 1 mGy.
S. D. Conzone et al., "Preparation and Properties of Radioactive Rhenium Glass Microspheres Intended for in Vivo Radioembolization Therapy," Journal of Biomedical Materials Research - Part A, John Wiley & Sons, Dec 1998.
The definitive version is available at http://dx.doi.org/10.1002/(SICI)1097-4636(19981215)42:4<617::AID-JBM19>3.0.CO;2-4
Materials Science and Engineering
Keywords and Phrases
Re-186; Re-188; Glass Microspheres; Liver Tumor Treatment; Rhenium Radioisotopes
Article - Journal
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