Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of disability and death in children and adults under 45, with approximately ten million new cases per year worldwide. Significant progress has been made in understanding the complex pathophysiological response to TBI; however, reducing the damage associated with the reactive oxygen species (ROS)-dependent secondary phase of the injury remains a substantial challenge. The development of an image-guided, Gd-conjugated, oxygen reactive polymer (ORP) to reduce ROS levels in damaged brain tissue is reported. ORP effectively sequesters ROS while remaining biocompatible even at elevated concentrations. ORP is retained in damaged brains of controlled cortical impact (CCI) mouse models of TBI for over 24 h when injected intravenously immediately and up to 3 h post-CCI. The polymer reduces neurodegeneration tenfold and gliosis twofold in these mouse models. ORP shows initial promise as an effective therapy for TBI and helps provide a better understanding of nanomaterial interaction with damaged brain.
J. Xu and M. Ypma and P. A. Chiarelli and J. Park and R. G. Ellenbogen and P. S. Stayton and P. D. Mourad and D. Lee and A. J. Convertine and F. M. Kievit, "Theranostic Oxygen Reactive Polymers for Treatment of Traumatic Brain Injury," Advanced Functional Materials, vol. 26, no. 23, pp. 4124-4133, Wiley-VCH Verlag, Jun 2016.
The definitive version is available at https://doi.org/10.1002/adfm.201504416
Materials Science and Engineering
Keywords and Phrases
antioxidant; concussion; image-guided; neuroprotection; RAFT
International Standard Serial Number (ISSN)
Article - Journal
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