In Vivo Evaluation of Scaffolds with a Grid-Like Microstructure Composed of a Mixture of Silicate (13-93) and Borate (13-93B3) Bioactive Glasses
A borate bioactive glass (designated 13-93B3) converts faster to hydroxyapatite (HA) than silicate 13-93 bioactive glass but recent studies have shown conflicting results for its capacity to repair rat calvarial defects. In this study, scaffolds composed of 13-93 and 13-93B3 glass alone and composite scaffolds composed of a mixture of 13-93 and 13-93B3 glasses were created with the same grid-like microstructure (porosity = 47%; filament diameter = 330 μm; pore width = 300 μm) using a robocasting technique. When implanted in rat calvarial defects in vivo, the scaffolds showed a decreasing capacity to regenerate bone with increasing volume fraction of 13-93B3 glass in the scaffolds. The percent new bone in the defects implanted with the 13-93 scaffolds (23 ± 4 % at 6 weeks and 28 ± 8% at 12 weeks) was significantly higher than in the defects implanted with the 13-93B3 scaffolds (6 ± 4 % at 6 weeks and 9 ± 7 % at 12 weeks). While the 13-93 glass was only partially converted to HA after 12 weeks in vivo, the 13-93B3 glass was almost fully converted within 6 weeks. Composite scaffolds composed of an optimized mixture of silicate 13-93 and borate 13-93B3 bioactive glasses may provide advantages for bone and tissue healing over scaffolds composed of 13-93 or 13-93B3 glass alone.
Y. Gu et al., "In Vivo Evaluation of Scaffolds with a Grid-Like Microstructure Composed of a Mixture of Silicate (13-93) and Borate (13-93B3) Bioactive Glasses," Ceramic Engineering and Science Proceedings, vol. 35, no. 5, pp. 53-64, American Ceramic Society, Jan 2014.
The definitive version is available at https://doi.org/10.1002/9781119040392.ch6
Advances in Bioceramics and Porous Ceramics - 38th International Conference on Advanced Ceramics and Composites (2014: Jan. 26-31, Daytona Beach, FL)
Materials Science and Engineering
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