In Vivo Evaluation of Scaffolds with a Grid-Like Microstructure Composed of a Mixture of Silicate (13-93) and Borate (13-93B3) Bioactive Glasses

Abstract

A borate bioactive glass (designated 13-93B3) converts faster to hydroxyapatite (HA) than silicate 13-93 bioactive glass but recent studies have shown conflicting results for its capacity to repair rat calvarial defects. In this study, scaffolds composed of 13-93 and 13-93B3 glass alone and composite scaffolds composed of a mixture of 13-93 and 13-93B3 glasses were created with the same grid-like microstructure (porosity = 47%; filament diameter = 330 μm; pore width = 300 μm) using a robocasting technique. When implanted in rat calvarial defects in vivo, the scaffolds showed a decreasing capacity to regenerate bone with increasing volume fraction of 13-93B3 glass in the scaffolds. The percent new bone in the defects implanted with the 13-93 scaffolds (23 ± 4 % at 6 weeks and 28 ± 8% at 12 weeks) was significantly higher than in the defects implanted with the 13-93B3 scaffolds (6 ± 4 % at 6 weeks and 9 ± 7 % at 12 weeks). While the 13-93 glass was only partially converted to HA after 12 weeks in vivo, the 13-93B3 glass was almost fully converted within 6 weeks. Composite scaffolds composed of an optimized mixture of silicate 13-93 and borate 13-93B3 bioactive glasses may provide advantages for bone and tissue healing over scaffolds composed of 13-93 or 13-93B3 glass alone.

Meeting Name

Advances in Bioceramics and Porous Ceramics - 38th International Conference on Advanced Ceramics and Composites (2014: Jan. 26-31, Daytona Beach, FL)

Department(s)

Materials Science and Engineering

International Standard Book Number (ISBN)

978-1119040439

International Standard Serial Number (ISSN)

0196-6219

Document Type

Article - Conference proceedings

Document Version

Citation

File Type

text

Language(s)

English

Rights

© 2014 American Ceramic Society, All rights reserved.

Publication Date

01 Jan 2014

Link to Full Text

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