Development of Implants Composed of Hollow Hydroxyapatite Microspheres for Bone Regeneration
This article will describe our recent studies on the development of implants composed of hollow hydroxyapatite (HA) microspheres to meet the need for improved synthetic materials for bone repair. Bone is the second most common transplanted tissue but problems with existing treatments such as autologous bone grafts and bone allografts have increased the need for synthetic bone graft substitutes. Using a novel glass conversion technique, hollow HA microspheres have been created with diameters in the range <100 to 1000 um, high surface area (>100 m2/g), a mesoporous shell wall (pore size 10-20 run), and controllable degradation rate. In addition to being bioactive and osteoconductive, the hollow HA microspheres have the ability to function as a device for controlled delivery of growth factors, such as bone morphogenetic protein-2(BMP2), that are known to stimulate bone formation. When loaded with BMP2, implants composed of hollow HA microspheres have shown a significant capacity to regenerate bone in a rat calvarial defect model. The preparation of implants composed of hollow HA microspheres, the release of growth factors from the microspheres in vitro, and the performance of the implants in vivo are discussed.
M. N. Rahaman et al., "Development of Implants Composed of Hollow Hydroxyapatite Microspheres for Bone Regeneration," Ceramic Transactions, vol. 251, pp. 45-56, American Ceramic Society, Jan 2014.
The definitive version is available at http://dx.doi.org/10.1002/9781118995235.ch5
Biomaterials Science: Processing, Properties and Applications IV - Materials Science and Technology Conference and Exhibition (2013: Oct. 27-31, Montreal, Canada)
Materials Science and Engineering
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