Influence of Cu Doping in Borosilicate Bioactive Glass and the Properties of its Derived Scaffolds
Copper doped borosilicate glasses (BG-Cu) were studied by means of FT-IR, Raman, UV-vis and NMR spectroscopies to investigate the changes that appeared in the structure of borosilicate glass matrix by doping copper ions. Micro-fil and immunohistochemistry analysis were applied to study the angiogenesis of its derived scaffolds in vivo. Results indicated that the Cu ions significantly increased the B-O bond of BO4 groups at 980 cm-1, while they decrease that of BO2O- groups at 1440-1470 cm-1 as shown by Raman spectra. A negative shift was observed from 11B and 29Si NMR spectra. The 11B NMR spectra exhibited a clear transformation from BO3 into BO4 groups, caused by the agglutination effect of the Cu ions and the charge balance of the agglomerate in the glass network, leading to a more stable glass network and lower ions release rate in the degradation process. Furthermore, the BG-Cu scaffolds significantly enhanced blood vessel formation in rat calvarial defects at 8 weeks post-implantation. Generally, it suggested that the introduction of Cu into borosilicate glass endowed glass and its derived scaffolds with good properties, and the cooperation of Cu with bioactive glass may pave a new way for tissue engineering.
H. Wang and S. Zhao and W. Xiao and J. Xue and Y. Shen and J. Zhou and W. Huang and M. N. Rahaman and C. Zhang and D. Wang, "Influence of Cu Doping in Borosilicate Bioactive Glass and the Properties of its Derived Scaffolds," Materials Science and Engineering C, vol. 58, pp. 194-203, Elsevier Ltd, Jan 2016.
The definitive version is available at http://dx.doi.org/10.1016/j.msec.2015.08.027
Materials Science and Engineering
International Standard Serial Number (ISSN)
Article - Journal
© 2016 Elsevier Ltd, All rights reserved.