Enhanced Osteointegration of Poly(Methylmethacrylate) Bone Cements by Incorporating Strontium-Containing Borate Bioactive Glass
Although poly(methylmethacrylate) (PMMA) cements are widely used in orthopaedics, they have numerous drawbacks. This study aimed to improve their bioactivity and osseointegration by incorporating strontium-containing borate bioactive glass (SrBG) as the reinforcement phase and bioactive filler of PMMA cement. The prepared SrBG/PMMA composite cements showed significantly decreased polymerization temperature when compared with PMMA and retained properties of appropriate setting time and high mechanical strength. The bioactivity of SrBG/PMMA composite cements was confirmed in vitro, evidenced by ion release (Ca, P, B and Sr) from SrBG particles. The cellular responses of MC3T3-E1 cells in vitro demonstrated that SrBG incorporation could promote adhesion, migration, proliferation and collagen secretion of cells. Furthermore, our in vivo investigation revealed that SrBG/PMMA composite cements presented better osseointegration than PMMA bone cement. SrBG in the composite cement could stimulate new-bone formation around the interface between the composite cement and host bone at eight and 12 weeks post-implantation, whereas PMMA bone cement only stimulated development of an intervening connective tissue layer. Consequently, the SrBG/PMMA composite cement may be a better alternative to PMMA cement in clinical applications and has promising orthopaedic applications by minimal invasive surgery.
X. Cui and C. Huang and M. Zhang and C. Ruan and S. Peng and L. Li and W. Liu and T. Wang and B. Li and W. Huang and M. N. Rahaman and W. W. Lu and H. Pan, "Enhanced Osteointegration of Poly(Methylmethacrylate) Bone Cements by Incorporating Strontium-Containing Borate Bioactive Glass," Journal of the Royal Society Interface, vol. 14, no. 131, Royal Society of London, Jun 2017.
The definitive version is available at http://dx.doi.org/10.1098/rsif.2016.1057
Materials Science and Engineering
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